Pernicious Anaemia Asking to Switch From Injections to Tablets — Free SCA Practice Case
Man with pernicious anaemia asking to switch from injections to tablets
Station Timer
Golden Minute
Initial Introduction
•Introduce yourself
•Ask an open question — "How can I help you today?"
•Listen — don't interrupt
•Catch early cues
Data Gathering
History, ICE & Diagnosis
Clinical Management
Diagnosis, Plan & Decisions
Safety Net
Follow-up & Close
Five cases are free: a live 12-minute consultation with an AI patient each, marked, and no card.
Materials for Candidate
Please review before starting the consultation
Full Name
Kayode Ogunleye
Age
60 years
Consultation Type
TelephoneAge
60
Situation
Telephone Consultation. Patient asked for a call about his B12 injections.
Reason for Encounter
"Would like to change his B12 injections to tablets."
Medical Records
- ●PMH: Pernicious anaemia diagnosed 9 years ago. Hypertension. Non diabetic hyperglycaemia.
- ●Medications: Hydroxocobalamin 1 mg intramuscular every 3 months. Amlodipine 5 mg once daily.
- ●Allergies: NKDA.
- ●Social: Piano tuner. Never smoked.
Recent Notes
- ●Practice nurse, 7 months ago: Hydroxocobalamin 1 mg intramuscular injection given.
- ●Appointments since: Three injection slots booked and cancelled by patient.
- ●NHS Health Check, 2 years ago: HbA1c 45 mmol/mol. BMI 29. BP 136/84. FBC normal.
Patient Script
For the friend playing the patient role
Character Overview: You are Kayode Ogunleye, a 60 year old piano tuner and technician for a piano showroom in Leicester. You were born in London to Nigerian parents and have lived in Leicester for thirty years with your wife Bisi, 58, who works as a school cook. Most days you drive to customers' homes, schools and churches across Leicestershire and Northamptonshire, and your jobs are booked three or four weeks ahead. About nine years ago you were found to be very low in B12 and have had an injection from the practice nurse every three months since. You were told you would need them for life and took in little else. Lenny, who works in the showroom workshop, takes a B12 tablet every morning, and you have asked for this call hoping to swap your injections for tablets too. You are taking the call in your van, parked on a customer's drive between jobs. You are warm, chatty and practical, a little hurried, and you play down anything to do with your own health.
Opening Sentence: "Hello, doctor, thanks for ringing me back. It's about my B12 injections. I've had them every three months for about nine years now, and a chap I work with just takes a tablet every morning for his. I'd much rather do that than keep trying to fit in the nurse. Oh, and my feet have been a bit tingly lately, but I'm sure that's just my age."
History if Asked (Data Gathering Phase)
- ●Where the idea came from: "Lenny in our workshop takes one every morning. If it's the same vitamin, why am I trailing into the surgery every few months?" If asked why Lenny takes tablets: "His diabetes tablets made his B12 drop, that's what he told me."
- ●What he knows about his own B12 problem (if asked): "They found it about nine years ago. I kept nodding off in the van and Bisi said I looked washed out. They said it was an autoimmune thing and I'd need the jabs for life. I'll be honest, I didn't take in much more than that."
- ●Last injection and missed appointments (if asked): "Must be six or seven months ago? I've cancelled a few. The nurse only does them in the daytime, and the last few months have been my busiest. Then I thought I'd sort out the tablets instead." He cancelled three in all and none is booked.
- ●Supplements (if asked about other medicines, vitamins or anything from the shops): "I bought a tub of vitamin B tablets from the supermarket about three weeks ago and I take one a day. I thought it'd tide me over. I haven't noticed any difference."
- ●The tingling: "The soles of both feet and my toes, both the same. It started about six weeks ago, maybe a bit more. It's a fizzing, like when your foot's been asleep and it's coming back, and a bit numb underneath, like thick socks. It's not painful, just odd. It started in my toes and now it's the whole of the sole, but it hasn't gone above my ankles. It's there most of the time, and I notice it most in bed at night." If asked about his hands: "No, my hands are fine. I'd soon know, with my job."
- ●Energy (if asked how he has been in himself): "If I'm honest, I've been flagging a bit in the afternoons this last month or so. A bit like before they found it, but nowhere near as bad as then."
Ideas, Concerns, Expectations
Gating note: Kayode does not raise any of the following himself. Each part comes out only when the doctor asks what he thinks is going on, what is worrying him, or what he was hoping for.
- ●Ideas: He thinks the injections may not do as much as they used to, and that a tablet every day would keep him topped up instead of one big dose that wears off. He puts his feet down to sitting in the van all day, or getting older. "With a tablet every day you'd be topped up all the time, wouldn't you? The feet, I put that down to sitting in the van all day." He has not connected the tingling with the late injection: "No. It never crossed my mind."
- ●Concerns: His first worry is work. "Every time I come in it's half a morning gone, and my jobs are booked weeks ahead." If the doctor explores further, especially about his feet, a bigger worry comes out, and his voice goes quieter: "If I'm honest, it's my brother. Femi's got diabetes and he lost the feeling in his feet. He had a sore on his foot he didn't even know was there, and last year they took one of his toes off."
- ●Expectations: He hoped the doctor would put tablets on his repeat prescription today so he could stop the injections. "I was hoping you could just put the tablets on my repeat, and then I wouldn't need to book the nurse at all."
If Asked: Medical History and Medications
Gating note: Kayode answers each of these plainly when the doctor asks about it.
- ●Other health problems and medicines: "Just my blood pressure. I've been on amlodipine for about six years, one a day, no problems with it. Nothing else apart from those supermarket vitamin tablets. No allergies that I know of."
- ●Blood sugar: "At my health check a couple of years ago they said my sugar was borderline. I couldn't fit the course round work. I don't think it's been checked since." He is not especially thirsty and is up once in the night for the loo, as always.
- ●The injections themselves: "I don't mind needles. It's the getting there that's the problem." If asked about giving them himself: "I've never done anything like that. I'd have a go if somebody showed me. Bisi's braver than me, mind."
- ●Family: "My brother Femi's 64, he's had diabetes for about fifteen years. Mum and Dad both lived well into their eighties."
Social History and Lifestyle Impact
- ●Work: Kayode is employed by the showroom, but part of his pay depends on the number of jobs he completes. He leaves home about half seven and is often not back until six. He is in Northampton all day Thursday and has a church in Market Harborough on Friday.
- ●Lifestyle impact: "It's just always there, and it bothers me when I'm trying to get off to sleep."
- ●Hobbies, alcohol and diet: "Two pints of bitter on a Friday, and two on a Sunday after church. That's it. Never smoked."
If Asked: Associated Symptoms
- ●If asked about unsteadiness (particularly in the dark or with his eyes closed), falls, weakness or stiffness in the legs, bladder or bowel problems, or back pain: "No, I'm steady. I get up for the loo in the night without the light on and I'm fine. My legs are strong, and my bladder and bowels are normal. No back trouble."
- ●If asked about eyesight, memory, concentration or mood: "All fine. I'm just fed up with the feet."
- ●If asked about breathlessness, chest pain, indigestion, trouble swallowing, being sick, weight loss, black stools or recent illness: "No, none of that. My weight's about the same."
- ●If asked about cuts, sores or burns on his feet: "Not that I've noticed." If asked about driving: "I can feel the pedals fine. It's just the fizzing."
Responses to Management (The Negotiation Phase)
- ●If the doctor says tablets are not suitable for him, or that the injections are for life:
- ●Reaction: Pushes back once, good naturedly. "But Lenny's fine on them. What's the harm in giving them a go?" If the doctor explains that his body cannot take in B12 from tablets the way Lenny's can: "So it's not that the tablets are weaker. It's me that can't take them in." If strong daily tablets are mentioned as a possibility later: "So it's not a never. Can we look at that again once my feet are sorted?"
- ●If the doctor links the tingling to the late injection, or says he needs injections more often for a while:
- ●Reaction: Sheepish. "I did cancel a few. So this is my own fault, then?" He settles if he is not made to feel blamed. About more frequent injections he is taken aback, then practical: "More often, not less. That's the opposite of what I rang for. How often? I'm in Northampton all day Thursday and I've got a church in Market Harborough on Friday." He agrees if the doctor works out a plan he can keep.
- ●If the doctor offers to teach him or Bisi to give the injections at home, or to book a run of appointments:
- ●Reaction: Interested. "I'd never have thought of that. I'd give it a go if someone showed me properly. Can I start straight away?"
- ●If the doctor asks him to come in to be examined, or to test his own feet or balance on the phone:
- ●Reaction: Relieved to be seen. "Yes, I'd rather someone had a proper look at my feet, to be honest." He asks whether he can come early in the morning or after four. If asked to test his feet or balance himself: "I'm sat in the van on a customer's drive. I'd rather you had a look at them properly."
- ●If the doctor arranges blood tests, or discusses the supermarket tablets:
- ●Reaction: "What are you checking for? Is that my sugar? That's how Femi's started." He also asks: "Will you check my B12 level while you're at it?" About the supermarket tablets: "So should I keep taking them, or are they a waste of money?"
- ●If the doctor talks about recovery, the stomach risk of his condition, or safety netting:
- ●Reaction: About recovery: "If it is the B12, does the feeling come back? Or is this how they'll stay now?" He is reassured by an honest answer. About the stomach risk, surprised: "Nobody's ever told me that. What should I look out for?" If safety netting is vague, such as "ring back if it gets worse": "Worse how? It's just fizzing at the moment. What would mean I shouldn't wait?"
Mark Scheme
Domain 1: Data Gathering and Diagnosis
Domain 2: Clinical Management and Medical Complexity
Domain 3: Relating to Others
Clinical Learning Points
The Core Dilemma and the Model Plan
- ●Kayode asks to swap three monthly injections for tablets because a colleague takes them. The skill is to ask why the colleague is deficient, to see that Kayode's autoimmune cause makes tablets the wrong answer now, and to notice that new tingling in both feet about four months after his last injection may be B12 neuropathy that needs treating without delay.
- ●Model plan: keep lifelong intramuscular injections. Give an injection today or within days without waiting for blood results, and increase the frequency for neurological symptoms, or seek haematology or neurology advice on the frequency (doing both is best). See him face to face within days to examine his feet. Send bloods for other causes, including an HbA1c. Prevent further gaps, explain recovery honestly, give specific safety netting and agree a date to reassess.
- ●Also acceptable: giving the injection promptly and agreeing the frequency with a specialist; offering to revisit high dose daily tablets later, once the nerve symptoms have settled, with specialist advice and close review, provided injections continue now; teaching him or Bisi to give the injections at home where local policy supports it, once any more frequent course is complete.
The Cause Decides the Route, and Why Tablets Fail Here
- ●NICE guideline NG239 (Vitamin B12 deficiency in over 16s, 2024) chooses oral or intramuscular replacement by cause, not convenience. Autoimmune gastritis, total gastrectomy or complete terminal ileal resection: lifelong intramuscular B12. Other malabsorption: consider intramuscular rather than oral, and if oral is used give at least 1 mg a day. Medicine induced deficiency (for example metformin or proton pump inhibitors): oral or intramuscular by judgement and preference. Dietary deficiency: oral replacement and diet advice.
- ●NG239 prefers autoimmune gastritis to pernicious anaemia, but patients and older records still use the old name. Lenny's deficiency is medicine induced, so tablets suit him. Kayode's is autoimmune, so the same tablets do not suit him.
- ●Without intrinsic factor, active absorption in the terminal ileum fails. Only a small fraction of a very large oral dose is absorbed passively, so the BNF sees little place for low dose oral B12 and says larger doses may work.
- ●NICE CKS describes daily doses of 500 to 1000 micrograms as a maintenance option after initial correction, using clinical judgement because absorption and adherence are concerns, and expert opinion reserves it for people who cannot tolerate injections and will take tablets reliably. Kayode tolerates injections, and no source supports switching while nerve symptoms are active or an injection is overdue.
- ●Over the counter B complex and multivitamin products usually contain microgram doses and are no substitute. Some contain folic acid, which without B12 can precipitate or worsen neuropathy (BNF).
New Neurological Symptoms on Maintenance Injections
- ●NG239 (1.6.11): if someone on injections has new or worse symptoms, increase the frequency if needed in line with the summary of product characteristics, think about alternative diagnoses and agree a date for reassessment. Do not delay replacement while waiting for results where there are neurological symptoms.
- ●BNF hydroxocobalamin with neurological involvement: 1 mg on alternate days until no further improvement, then 1 mg every 2 months. Without neurological involvement: 1 mg three times a week for 2 weeks, then 1 mg every 2 to 3 months.
- ●CKS advises urgent advice from a neurologist or haematologist where there is neurological involvement; if it is not immediately available, consider the alternate day regimen. NG239 does not mention specialist advice. Both routes are reasonable, and doing both is best.
- ●Untreated B12 neuropathy can progress to subacute combined degeneration of the cord, with loss of joint position and vibration sense, sensory ataxia and spasticity. A gap of several months is a plausible contributor but does not prove the cause, so other causes are checked at the same time.
Assessing Numb Feet and Looking for Other Causes
- ●History: distribution (symmetrical, starting in the toes), duration, spread, pain, hands, and unsteadiness in the dark or with the eyes closed. Red flags needing same day assessment: unsteadiness or falls, leg weakness or stiffness, rapidly ascending numbness, new bladder or bowel dysfunction.
- ●Examination must be in person: light touch and pinprick, vibration with a 128 Hz tuning fork, joint position, reflexes (absent ankle jerks with extensor plantars is the classic combined picture), power, gait, Romberg's test and a foot skin check, with a 10 g monofilament if diabetes is possible. A patient cannot examine himself reliably by phone.
- ●Other causes of symmetrical sensory neuropathy include diabetes, alcohol, hypothyroidism, chronic kidney disease and medicines. Kayode's HbA1c of 45 mmol/mol is in the high risk range of 42 to 47 (NICE PH38), which calls for a test at least yearly; 48 or above supports type 2 diabetes. A result two years ago does not exclude diabetes now.
- ●Sensible bloods: HbA1c, full blood count, folate, ferritin (autoimmune gastritis also impairs iron absorption), thyroid function, kidney and liver function. Do not repeat a serum B12 in someone having injections (NG239 1.6.10): levels rise with injections whatever the response, his supplement could raise the level without treating the deficiency (1.3.8), and a low result would not change the plan.
- ●If folate is low, give folic acid only with B12 replacement under way.
Recovery and Keeping Injections on Time
- ●NG239 (1.5.1): symptoms may start to improve within 2 weeks but this can take up to 3 months, complete resolution can take much longer, and they can get worse at first. CKS notes recovery usually begins within a week, with resolution most often between 6 weeks and 3 months. Recovery is not guaranteed after a long delay, so be honest without being fatalistic.
- ●Hydroxocobalamin is retained longer than cyanocobalamin, so maintenance can be every 3 months; after a neurological course it is every 2 months. Practical options: a series of appointments booked ahead, early, evening or weekend slots, combining injections with other reviews, and recall reminders.
- ●Self administration: NG239 made a research recommendation rather than a recommendation for or against, and subcutaneous use would be off label. Some practices and integrated care boards support trained self or carer administration of intramuscular hydroxocobalamin under a local policy.
- ●For an irreversible cause, treatment is never withdrawn because symptoms have resolved (NG239 1.6.12).
Autoimmune Gastritis and the Stomach
- ●People with autoimmune gastritis are at higher risk of gastric neuroendocrine tumours and possibly gastric adenocarcinoma (NG239 1.7.1). New or worsening upper gastrointestinal symptoms such as dyspepsia, nausea or vomiting should prompt consideration of endoscopy (1.7.2), following NICE NG12: suspected cancer pathway referral for dysphagia, or for people aged 55 and over with weight loss and upper abdominal pain, reflux or dyspepsia.
- ●CKS advises gastroenterology referral for pernicious anaemia with gastrointestinal symptoms, especially with coexisting iron deficiency. NG239 found no evidence for surveillance, so the safeguard in primary care is that the patient knows which symptoms to report.
Safety Netting and Follow Up
- ●Same day: unsteadiness or falls, weakness or stiffness in the legs, numbness spreading up the legs or into the hands, or new bladder or bowel dysfunction.
- ●Contact the practice: an unnoticed sore or injury on the feet, new indigestion, swallowing difficulty, vomiting or weight loss.
- ●Agree a date to reassess the tingling and review the bloods. Refer to haematology or neurology if it does not improve or worsens on frequent injections, or if examination suggests spinal cord involvement. Manage a raised HbA1c in its own right, with foot protection advice if diabetes is confirmed.
- ●The MHRA (December 2023) advises that B12 contains cobalt, so patients should seek advice if allergic skin reactions develop on treatment.
Common Mistakes in This Station
- ●Agreeing to tablets because a colleague takes them, without asking why the colleague is deficient.
- ●Treating the tingling as a throwaway remark and not working out how overdue the injection is.
- ●Waiting for blood results, or checking a B12 level, before giving the overdue injection.
- ●Restarting three monthly injections unchanged despite new neurological symptoms.
- ●Assuming the cause is B12 alone and missing the raised HbA1c.
- ●Trying to assess numb feet over the phone instead of examining in person.
- ●Insisting on injections but offering nothing to make attendance workable, so the gap recurs.
- ●Promising the feeling will definitely come back, or vague safety netting with no specific red flags.
Mapped to the RCGP curriculum topic: Haematology.
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