Man Whose Sildenafil Is Not Working — Free SCA Practice Case
Man whose sildenafil is not working
Station Timer
Golden Minute
Initial Introduction
•Introduce yourself
•Ask an open question — "How can I help you today?"
•Listen — don't interrupt
•Catch early cues
Data Gathering
History, ICE & Diagnosis
Clinical Management
Diagnosis, Plan & Decisions
Safety Net
Follow-up & Close
Five cases are free: a live 12-minute consultation with an AI patient each, marked, and no card.
Materials for Candidate
Please review before starting the consultation
Full Name
Clement Ashdown
Age
58 years
Consultation Type
VideoAge
58
Situation
Video Consultation. Review booked by the patient.
Reason for Encounter
"The sildenafil I was given doesn't work. I'd like to talk about it."
Medical Records
- ●PMH: Hypertension for 6 years. Ex smoker.
- ●Medications: Ramipril 5 mg once daily. Sildenafil 50 mg tablets, four supplied 2 months ago.
- ●Allergies: NKDA.
- ●Social: Regional account manager. Married.
- ●Results (11 months ago): HbA1c 39 mmol/mol, total cholesterol 5.6 mmol/L, HDL 1.1 mmol/L, eGFR 82.
- ●Last BP (4 months ago): 136/84.
Patient Script
For the friend playing the patient role
Character Overview: You are Clement Ashdown, a 58 year old regional account manager for a packaging company. You drive about 300 miles a week visiting customers and spend long evenings on the laptop. You live with your wife Odette, who is 56 and works as a dental receptionist. Your son Rufus is 29 and lives in Leeds. You have had high blood pressure for six years, controlled on ramipril. For about 18 months your erections have been getting weaker. Two months ago you finally raised it and were given four sildenafil tablets. You have tried two and nothing happened, so you have decided you are one of the men it just will not work for. You are embarrassed, rather deflated and a little curt, and you joke to cover how low you feel. You speak plainly. If the doctor is matter of fact and kind, you relax and become more open, and you start to sound hopeful.
Opening Sentence: "Morning, doctor. The sildenafil you gave me hasn't done a thing. I tried it twice, nothing, so I reckon I'm one of those men it just won't work for. I wondered if there's anything else, or whether that's me done."
History if Asked (Data Gathering Phase)
- ●How the problem started: "About eighteen months ago, very gradually. First it was keeping an erection that went. Now it's often not firm enough to go ahead at all. I'd say it works perhaps three times in ten."
- ●Morning erections: "They've nearly stopped. I used to wake with one most days. Now it's once a week at best."
- ●Is it the same in every situation: "Yes. It's the same with Odette and on my own. It isn't just nerves on the night."
- ●Desire, ejaculation and orgasm: "My interest is lower than it was a couple of years ago. I think about sex less often. When things do work, ejaculation and orgasm are normal. There is no pain and no bend, and I've never had an injury down there."
- ●The first sildenafil attempt: "A Saturday. We'd had a roast dinner at a pub, with steak pie, chips and two glasses of wine. We got home, got into bed, and I took one 50 milligram tablet. About twenty minutes later we gave up. I had a bit of a flushed face and a mild headache, nothing more."
- ●The second attempt: "A couple of weeks after that, same idea. We'd had a curry with a couple of beers. I took the tablet when we went up and we lay there waiting."
- ●What happened while waiting: "To be honest, nothing. We'd agreed I'd take the tablet and we'd see whether it did the job. We were both too embarrassed to try anything, so we put the light out."
- ●Instructions he was given: "The doctor said to take one when I needed it. I didn't read the leaflet properly. It's still in the box."
- ●Tablets left: "Two. I haven't tried again because I thought what's the point."
- ●Priapism or side effects: "No long erections. No visual changes, no dizziness, no chest pain after the tablets."
Ideas, Concerns, Expectations
Gating note: Clement does not raise any of the following himself. Each part comes out only when the doctor asks what he thinks is going on, what worries him, or what he was hoping for.
- ●Ideas: He thinks his body has simply worn out, and that he is a non responder because the tablet did nothing at all. He has wondered whether the ramipril is to blame. "I've read the blood pressure tablet can do it. Maybe that's why nothing works."
- ●Concerns: He fears he is failing Odette, that she will lose interest in him, and that it means something is wrong with his heart, because his father needed a bypass in his sixties. He is also worried that stronger tablets might be dangerous with his blood pressure. "Is this the start of heart trouble? That's what happened to Dad."
- ●Expectations: He hopes for a tablet that works, and he wants to be told straight whether it is worth carrying on. He does not want to be sent away or told it is just age. "If there's something that works, I'll do what it takes. I just don't want to be fobbed off."
If Asked: Medical History and Medications
Gating note: Clement answers each of these plainly when the doctor asks about it.
- ●Other health problems: "Just the blood pressure. No diabetes, my sugar was fine last year. Cholesterol was a bit high at 5.6 and I was told to watch my diet."
- ●Heart history: "No heart attack, no angina, no stroke. I've never had chest tightness, and no palpitations or blackouts."
- ●Exercise tolerance: "I can climb two flights of stairs without stopping. I walk the dog for half an hour at a good pace and I'm fine."
- ●Blood pressure: "Odette bought a home cuff. I check it now and then and it's usually around 134 over 82."
- ●Medicines: "Just ramipril 5 milligrams. No other tablets, nothing from the chemist or online, no herbal products or supplements."
- ●Nitrates, nicorandil, alpha blockers and poppers: "No to all of those. I've never used poppers."
- ●Eyes and sickle cell: "No eye problems and nothing like sickle cell."
- ●Urinary symptoms: "I get up once in the night. The stream is fine, no dribbling, no pain."
- ●Diabetes symptoms: "No excess thirst or passing water."
- ●Surgery, injury and cycling: "No operations around the pelvis, no injuries, and I don't cycle."
- ●Allergies: "None."
- ●Family history: "Dad had a bypass at 64 and died at 71. No other heart problems or diabetes."
Social History and Lifestyle Impact
- ●Work and home: Clement does a lot of driving and works late. He sits for most of the day. Odette is supportive. She knows about the tablets and has been understanding, but they have both avoided the subject since. He would be happy for her to join a later conversation if that would help.
- ●Smoking: Smoked about 10 a day until 12 years ago.
- ●Alcohol: About a glass of wine most evenings, roughly 14 units a week. He has no wish to stop completely but is willing to cut down.
- ●Weight and activity: About 15 stone. He stopped going to the gym a year ago because he felt flat and tired. His diet is poor on the road, with lots of services food.
- ●Mood: He feels low about this problem and a bit flat in general, but there is no persistent low mood, no loss of interest in everything and no thoughts of self harm. He feels anxious before sex now, expecting it to fail.
- ●Availability to be seen: Works from home on Thursday and could come at 8.30 in the morning for bloods and a check.
If Asked: Associated Symptoms
Gating note: Clement answers these only when asked.
- ●If asked about tiredness, energy or drive: "Yes. For the past year or so I've been tired and flat, and I've lost motivation. I put it down to work and age."
- ●If asked about shaving, body hair, muscle or breast changes: "I shave less often than I used to. I haven't noticed breast changes."
- ●If asked about sleep: "I sleep alright, apart from the once in the night."
- ●If asked about headaches or vision changes: "No. The headache after the first tablet was mild and brief."
Responses to Management (The Negotiation Phase)
- ●If the doctor explains why the tablets may not have worked (the heavy meal, the timing, the need for stimulation, only two tries at the starting dose):
- ●Reaction: Surprised and a little embarrassed. "Nobody told me that. So the dinner got in the way? And we just lay there?" He becomes hopeful: "So it might actually work properly if I do it right." He asks how long before sex to take it and whether he has to skip dinner.
- ●If the doctor offers a higher dose of the same tablet or a different tablet:
- ●Reaction: Practical. "Is a stronger dose safe with my blood pressure tablet?" He asks which suits him better. He says they often go out on a Friday night and would like something that does not depend on what he eats. He accepts either choice if the reasons are clear, and he asks how many tablets he will get. "Last time I only had four."
- ●If the doctor arranges blood tests, a blood pressure and weight check, or mentions testosterone:
- ●Reaction: Wary. "Why testosterone? Is that the injections thing?" He worries again that this is his heart. If it is explained as routine checking that the problem can be a sign of blood vessel health, and that a low hormone level can stop tablets working, he agrees and says Thursday at 8.30 suits him. "Can Odette come to the next appointment?"
- ●If the doctor raises alcohol, weight, exercise or the blood pressure tablet:
- ●Reaction: A little defensive, then open. "Do I have to give up the wine?" He accepts cutting down if given a specific limit. He asks whether he should stop the ramipril. "I don't want my blood pressure going up instead."
- ●If the doctor describes side effects, dangers or what to avoid:
- ●Reaction: Attentive. "What mustn't I take with it?" "What if my chest hurts?" He wants clear instructions on when to seek help and repeats them back accurately.
- ●If the doctor describes follow up and what happens if this does not work:
- ●Reaction: Relieved. "And if that fails as well?" He is reassured to hear that there are other treatments through a specialist. He agrees to a review in about six to eight weeks and says, "At least now I know what I was doing wrong."
Mark Scheme
Domain 1: Data Gathering and Diagnosis
Domain 2: Clinical Management and Medical Complexity
Domain 3: Relating to Others
Clinical Learning Points
The Core Dilemma and the Model Plan
Clement is a 58 year old man with controlled hypertension who has written off sildenafil after two attempts. The central point is that he has not had a fair trial. Both tablets were a 50 mg starting dose, taken after a large meal with alcohol, about 20 minutes before bed, with no sexual stimulation. Food slows the absorption of sildenafil by about an hour, and PDE5 inhibitors do not cause an erection by themselves: they need sexual stimulation. The model plan is: take a full erectile, medication and cardiovascular history; confirm no nitrates, nicorandil or poppers; judge cardiac risk of sexual activity as low; explain why the trial was inadequate; offer either optimised sildenafil or a switch to tadalafil; arrange a face to face check with blood pressure, weight, HbA1c, lipids, cardiovascular risk and a morning total testosterone; address anxiety and involve his wife if he wishes; give a supply for several attempts; safety net; review in 6 to 8 weeks.
Acceptable alternatives that all pass: sildenafil 100 mg taken on a lighter stomach about an hour before sex, with stimulation, over 4 to 8 attempts; or tadalafil 10 mg on demand, which is not affected by food, increasing to 20 mg if needed; or tadalafil 5 mg once daily for men wanting spontaneity. Vardenafil or avanafil is also reasonable.
Why the First Attempts Failed
Sildenafil is taken about an hour before sexual activity, and longer if taken with food. CKS states that a meal reduces the rate of absorption by a mean of about an hour. Alcohol can itself impair erections. Clement took a tablet 20 minutes after dinner and gave up soon after, so the drug would not have reached its peak. He also waited passively with no stimulation, which is essential, and two attempts is too few.
CKS advises ensuring the drug is taken correctly before changing dose or regimen. Tadalafil absorption is not affected by food and its effect lasts much longer, so it suits men who eat out or want a wider window.
Dose, Number of Attempts and Switching
CKS suggests increasing to the maximum tolerated dose, and trying each PDE5 inhibitor 4 to 8 times at that dose before switching. A man is classed as a non responder only after at least two different PDE5 inhibitors have been tried in turn at the maximum tolerated dose. For sildenafil the licensed range is 25 mg to 100 mg, taken no more than once a day, so Clement has not yet reached the top of the range.
CKS also notes that tadalafil can be given once daily at 5 mg for men who want spontaneity or who have sex at least twice a week. The NHS generally supplies one dose a week, but more can be prescribed if clinically appropriate, which matters because four tablets cannot support a proper trial.
Safety Before Prescribing
Nitrates, nicorandil and amyl nitrate (poppers) are absolutely contraindicated with PDE5 inhibitors because of the risk of severe hypotension, so these must be asked about. The candidate should also ask about alpha blockers (postural hypotension) and about recent heart attack or stroke, unstable angina, severe heart failure, and a history of non-arteritic anterior ischaemic optic neuropathy (NAION), which the BNF and CKS list as a contraindication. Ramipril on its own is not a contraindication.
Clement has controlled hypertension, no angina or past cardiac events, and good exercise tolerance, such as two flights of stairs and a brisk dog walk. The CKS cardiac risk grouping (from the Princeton III consensus) calls fewer than three coronary risk factors, excluding sex, low risk, and three or more intermediate risk. Clement has several (age, hypertension, a sedentary job, weight, borderline lipids), so a strict count is intermediate. CKS says intermediate risk calls for clinical judgement, and that exercise tolerance gives a good estimate of the risk of sexual activity. His symptom free good exercise tolerance supports starting treatment now, whether he is labelled low risk or intermediate with a reasoned decision. Seeking cardiology advice is also acceptable if the candidate explains why. High risk, such as unstable angina, uncontrolled hypertension or recent infarction, means advising against sexual activity until a cardiologist has assessed him.
Erectile Dysfunction as a Marker of Vascular Disease
CKS states that erectile dysfunction may be an early marker of coronary artery or endocrine disease. For every man, it advises blood tests for HbA1c or fasting glucose and a lipid profile, a calculation of 10 year cardiovascular risk with management as for NICE cardiovascular risk guidance, and measurement of blood pressure, heart rate, waist circumference and BMI. Clement has an ex smoking history, 14 units of alcohol a week, a weight of about 15 stone, a total cholesterol of 5.6 mmol/L with an HDL of 1.1 mmol/L, and a father with a bypass in his sixties. His HbA1c of 39 was normal. His risk score should be calculated and used to discuss prevention.
Lifestyle advice matters: weight loss, activity and keeping alcohol within 14 units a week. Do not stop ramipril: CKS says that for most men treating the underlying condition is more likely to help than changing the medicines. Herbal and online products may contain unlicensed active ingredients and should not be recommended.
Testosterone: When to Check It
CKS advises a fasting total testosterone between 9 and 11 am for men with erectile dysfunction, and repeat testing with FSH, LH, sex hormone binding globulin and prolactin if the level is low or borderline. Clement has gradual onset, falling morning erections, lower desire and a year of tiredness. Both the BSSM guideline and CKS state that low testosterone may reduce the response to PDE5 inhibitors, and correcting it may improve it.
The decision to treat is not made in general practice. If the level is low, the plan is a repeat sample and the other hormone tests, followed by advice from or referral to endocrinology before testosterone is considered. Starting the correct PDE5 plan while arranging the test is ideal.
Examination, Referral and Follow Up
A video call cannot examine blood pressure, weight, genitals or secondary sexual characteristics. The candidate should arrange a face to face visit within days. Review is advised 6 to 8 weeks after starting or changing treatment, to check how well it works, tolerability and satisfaction. If two PDE5 inhibitors at the maximum tolerated dose fail, or they are contraindicated, refer to urology, where options include vacuum devices, alprostadil injections or urethral systems, and other specialist treatments. Refer to endocrinology if testosterone is low or other hormones are abnormal.
Anxiety, His Wife and the Conversation
Performance anxiety turns each failed attempt into the next one. Clement is anxious before sex and the couple have avoided the subject. A good candidate acknowledges the embarrassment, asks permission, uses plain words, explains that the problem is common and treatable, and invites Odette to a later visit if he wants. Intimacy without pressure to perform, and psychosexual counselling if difficulties persist, help alongside medicine.
Safety Netting
He should seek urgent help for an erection lasting more than 4 hours, which is rare with oral PDE5 inhibitors, for chest pain after taking a tablet, and for sudden loss of vision or hearing. Chest pain after a tablet should be assessed urgently and nitrates should not be given for at least 24 hours after sildenafil and 48 hours after tadalafil. He should also report dizziness or fainting.
Common Mistakes in This Station
- ●Accepting that sildenafil has failed and labelling him a non responder after two attempts at the starting dose.
- ●Re prescribing the same tablet without advice on food, timing and stimulation.
- ●Not asking about nitrates, nicorandil, poppers and alpha blockers.
- ●Failing to assess cardiac risk, or telling a symptom free man with good exercise tolerance to avoid sex without reasons.
- ●Skipping blood pressure, HbA1c, lipids and cardiovascular risk because the problem seems purely sexual.
- ●Starting testosterone, or ignoring it, instead of arranging a morning total testosterone.
- ●Stopping ramipril because of the erectile problem.
- ●Prescribing too few tablets for a proper trial, or giving no follow up and no safety net.
Mapped to the RCGP curriculum topic: Sexual Health.
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