Low Cardiovascular Risk Asking for A Statin — Free SCA Practice Case
Woman with a low cardiovascular risk asking for a statin
Station Timer
Golden Minute
Initial Introduction
•Introduce yourself
•Ask an open question — "How can I help you today?"
•Listen — don't interrupt
•Catch early cues
Data Gathering
History, ICE & Diagnosis
Clinical Management
Diagnosis, Plan & Decisions
Safety Net
Follow-up & Close
Five cases are free: a live 12-minute consultation with an AI patient each, marked, and no card.
Materials for Candidate
Please review before starting the consultation
Full Name
Stella Georgiou
Age
50 years
Consultation Type
TelephoneAge
50
Situation
Telephone Consultation. Callback requested.
Reason for Encounter
"Had my NHS Health Check two weeks ago. My cholesterol was 6.4. I would like to start a statin please."
Medical Records
- ●PMH: Nil significant.
- ●Medications: None.
- ●Allergies: NKDA.
- ●Social: Never smoked. School business manager.
Recent Notes
- ●NHS Health Check, 2 weeks ago: BP 136/84, BMI 28.6, AUDIT C 5. No first degree relative with coronary heart disease under 60. Greek Cypriot. QRISK3 3.0%.
- ●Non fasting bloods: Total cholesterol 6.4, HDL 1.2, ratio 5.3, non HDL 5.2, LDL 4.3, triglycerides 1.9 mmol/L. HbA1c 37 mmol/mol.
Patient Script
For the friend playing the patient role
Character Overview: You are Stella Georgiou, a 50 year old school business manager at a primary school in north London, taking this call in your office at lunchtime with the door shut. You are Greek Cypriot, born and brought up in London, and live with your husband Andreas, who runs a small printing firm. Your children Christina, 23, and Nikos, 20, have left home. Your mum, Androulla, is 83. She was diagnosed with Alzheimer's disease at 77 and moved into a nursing home seven months ago after wandering at night and falling. You visit her most evenings on the way home from work, and your brother Costas goes at weekends. Three weeks ago you read an article in a Sunday paper saying a big study had found that people taking statins were less likely to get dementia. Then your NHS Health Check came back with a cholesterol of 6.4, and you decided you want to start a statin now. You are organised, quick and polite, and sound brisk and businesslike at first. Underneath you are grieving for your mum and frightened of ending up like her. You do not mention dementia or your mum until the doctor asks what is behind the request. When you talk about the last visit your voice catches and you slow down.
Opening Sentence: "Hello, thanks for calling me back. I had my health check a couple of weeks ago and my cholesterol came back at six point four, so I'd like to start a statin, please. I'd like to get going on it straight away."
History if Asked (Data Gathering Phase)
- ●What she was told at the health check: "The lady said my risk was four percent and that was low. She gave me a leaflet and said a statin was something I'd have to ask a doctor about."
- ●Why she wants a statin (her first answer): "Well, six point four is high, isn't it? And from what I've read they do you good in more ways than one. I want to be on the front foot with this." She explains "more ways than one" only if asked.
- ●Heart and stroke symptoms: "No, nothing. No chest pains, I'm not out of breath, my heart doesn't race. No weakness, no funny speech, nothing with my eyesight."
- ●Family history of heart disease: "Dad had a heart attack when he was seventy four. He died at eighty, a chest infection. Costas is fifty four, he's on blood pressure tablets and takes an aspirin every day off his own bat. Nobody's had a heart attack young, or been told their cholesterol is sky high."
- ●Her mum's diagnosis and family history of dementia: "Mum was diagnosed at seventy seven. Her older sister in Cyprus went the same way, but she was in her late eighties. Nobody's had it young, nobody in their fifties or sixties."
- ●Her own memory: "No, honestly, my memory's fine. I'm the one at school who remembers every child's name. It's not that. It's what might be coming."
- ●Mood and sleep: "I'm sad about Mum, of course I am. It's like losing her slowly. But I'm not depressed, I still enjoy things. No thoughts of harming myself. A couple of nights a week I find it hard to get off to sleep and lie there thinking about her."
Ideas, Concerns, Expectations
Gating note: Stella does not raise any of the following herself. Each part comes out only when the doctor asks what she meant by "more ways than one", what she has read, what is behind the request, what she is worried about, or what she was hoping for.
- ●Ideas: She has read that statins prevent dementia. If asked: "There was a big article in the Sunday paper. It said a huge study found people on statins were much less likely to get dementia. It makes sense, doesn't it? If it keeps the blood vessels clean for your heart, it must do the same for your brain."
- ●Concerns: Her mum, and becoming like her. If asked what is worrying her: "My mum's got Alzheimer's. She's in a nursing home now. I go in most evenings after work." If the doctor explores further, her voice catches and she slows down: "Last Tuesday she looked straight at me and asked when her daughter was coming to visit. I just sat there holding her hand." Then, quietly: "Is that me in thirty years? I don't want Christina and Nikos doing what I'm doing."
- ●Expectations: She wants a statin prescription today, and anything else she can do to protect her memory. If asked: "I was hoping you'd just start me on one today. And if there's anything else I can do for my brain, I want to know. What I don't want is another leaflet and a pat on the head."
If Asked: Medical History and Medications
Gating note: Stella answers each of these plainly when the doctor asks about it. The following are all negative: high blood pressure in pregnancy, migraines, arthritis or lupus, mental health treatment, steroids, kidney or liver problems, diabetes, thyroid symptoms (she is tired some days but blames the late nights) and muscle aches.
- ●Past illnesses and prescribed medicines: "Nothing really. Two normal pregnancies. I don't take anything regularly."
- ●Supplements: "I started some omega 3 fish oil capsules about three weeks ago, because I read they're good for the brain. Nothing else."
- ●Periods and contraception: "All over the place for about a year. My last one was about four months ago. A few hot flushes at night. Andreas had the snip after Nikos was born, and they checked it had worked."
Social History and Lifestyle Impact
Gating note: Stella shares this naturally when the doctor asks about her lifestyle or home life.
- ●Work and caring: Full time in the school office. She visits the nursing home most evenings. "By the time I get home it's gone eight and I'm wiped out."
- ●Alcohol: "Since Mum went into the home I have a big glass of white wine when I get in, five or six nights a week. Before that it was a couple of glasses at the weekend. Never more than the one." If asked about the size: "The large ones."
- ●Exercise: "I used to walk with my friend Joanne every Sunday and swim on Wednesdays. I've stopped both in the last year and a half."
- ●Diet and weight: "Proper Cypriot food, lots of olive oil, salads, beans and fish. But I eat halloumi most days, pick at the biscuits in the office, and we get a takeaway every Friday. I've put on about half a stone."
If Asked: Associated Symptoms
Gating note: Answers are brief and natural. The following are all negative: chest tightness on exertion, palpitations, calf pain on walking, forgetfulness, losing words, thirst or passing a lot of urine, and lumps in her tendons or around her eyes. She is breathless only on the stairs at the home if she rushes.
Responses to Management (The Negotiation Phase)
- ●If the doctor says her risk is under 10% so she does not need a statin, or explains what four percent means:
- ●Reaction: Frustrated. "So I just wait until my numbers get worse?" Once it is put as 3 in 100 women like her over 10 years: "Okay, that does sound small. But that's my heart. The bit I really care about is my brain."
- ●If the doctor explains that trials have not shown statins prevent dementia, says a statin will protect her, or agrees without discussing benefits and harms:
- ●Reaction: Deflated, then challenging: "But the article said people on them were much less likely to get it. Was that just made up?" Once the newspaper study and the trials are explained: "So it might help, it might not, and nobody actually knows. That's disappointing, but at least you're being straight with me." If told a statin will protect her, or it is simply agreed: "Oh, that's exactly what I hoped. It'll help with my memory in the long run, won't it?"
- ●If the doctor gives the heart benefit and side effects in numbers, mentions memory problems with statins, or leaves the decision with her:
- ●Reaction: "So for my heart it's maybe about one in a hundred, and for my brain nobody knows. And what are the chances of side effects?" On memory, alarmed: "Hang on, they can make your memory worse?" She settles if told it is uncommon, usually settles on stopping, and that there is no good evidence statins cause dementia. Given the choice she decides to start, and will do the lifestyle changes as well. If lifestyle change is suggested first, she asks to start the statin alongside. If the doctor refuses to prescribe: hurt. "I haven't earned it yet?"
- ●If the doctor raises a blood test, pregnancy, the fish oils, aspirin or safety netting:
- ●Reaction: Practical. "Can I do the blood test before work? Do I wait for the result before I start?" On pregnancy, amused: "At fifty? Andreas had the snip." On the fish oils: "So I've been wasting my money?" On aspirin: "Should I be taking one like Costas?" On vague safety netting: "What would I actually be looking out for?"
- ●If the doctor discusses her family history of dementia, or her risk of ending up like her mum:
- ●Reaction: Quiet. "Be honest with me. Am I going to end up like Mum?" Asked about a gene test: "Is there a test that would tell me if I've got the gene? I'd rather know." If told there is none on the NHS: "So there's no way of knowing. I suppose that might be a good thing."
- ●If the doctor raises her drinking, her exercise or how she is coping as a carer:
- ●Reaction: On drinking, a little defensive, then honest: "It's my one bit of me time. It's not like I'm getting drunk." Given a limit with drink free days: "I could do without it in the week." On exercise: "I could ring Joanne about Sundays again." Offered carer support such as a helpline or dementia nurse: surprised and touched. "I didn't know there was anything like that for people like me. Yes, that would help."
Mark Scheme
Domain 1: Data Gathering and Diagnosis
Domain 2: Clinical Management and Medical Complexity
Domain 3: Relating to Others
Clinical Learning Points
The Core Dilemma and the Model Plan
- ●Stella is a healthy 50 year old non smoker with a 10 year cardiovascular risk of 3.0% who asks for a statin. Her real reason is a newspaper report that statins prevent dementia, which her mother has. The task is not to grant or refuse a prescription. It is to find the real question, answer it honestly, and support an informed decision about a treatment whose proven benefit for her heart is small.
- ●Model answer: find the dementia motive, explain 3% in natural frequencies, give an honest answer on statins and dementia, give benefits and harms in numbers, and honour her informed choice. If she chooses to start, prescribe atorvastatin 20 mg once daily with baseline liver and kidney tests, pregnancy and interaction advice, a lipid and ALT check at 2 to 3 months, specific safety netting and a plan for her alcohol, activity and diet, and offer carer support.
- ●Also acceptable: offering lifestyle change first with a planned reassessment, provided the statin is presented as available now if she prefers; using a lifetime risk tool to frame her longer term risk; or, if she decides against a statin, recording this and leaving the door open.
QRISK3 and Talking About Absolute Risk
- ●NICE guideline NG238 (Cardiovascular disease: risk assessment and reduction, including lipid modification, 2023) recommends QRISK3 for people aged 25 to 84 without cardiovascular disease. It combines age, sex, ethnicity, postcode, smoking, diabetes, family history, kidney disease, atrial fibrillation, treated hypertension, migraine, rheumatoid arthritis, lupus, severe mental illness, steroids, the total to HDL cholesterol ratio, blood pressure and BMI. Her total cholesterol of 6.4 mmol/L is raised, but with normal blood pressure, no smoking and no diabetes her score is low; the postcode moves it between roughly 3% and 5%.
- ●Risk tools may underestimate risk with HIV, recent smoking cessation, severe mental illness or inflammatory disorders. QRISK3 should not be used in type 1 diabetes, chronic kidney disease or familial hypercholesterolaemia (FH). Family history counts only if a first degree relative had coronary heart disease under 60, so her father's heart attack at 74 does not. Total cholesterol above 9.0 or non HDL above 7.5 mmol/L should prompt specialist assessment for FH; hers does not.
- ●Natural frequencies work best: "Of 100 women like you, about 3 would have a heart attack or stroke in the next 10 years and 97 would not." The NICE decision aid "Should I take a statin?" does not show risks this low, but at her risk a statin prevents roughly 1 event per 100 women over 10 years. Harms: about 2 in 100 get muscle pain caused by the statin, about 3 extra in 10,000 severe muscle damage and about 1 in 100 type 2 diabetes.
Statins Below 10%
- ●NG238 recommends atorvastatin 20 mg for primary prevention at a QRISK3 of 10% or more, and says not to rule it out below 10% if the person has an informed preference for one (1.6.8).
- ●Discuss the benefits of lifestyle change and offer to reassess risk afterwards, alongside her preference and not as a hurdle. Give absolute risks, find out what she already believes, and document the decision.
- ●Either decision is reasonable once she is informed. Prescribing at her request follows the guideline; refusing because she is below the threshold does not.
Statins and Dementia
- ●The Cochrane review "Statins for the prevention of dementia" (2016) included two large randomised trials of over 26,000 people at vascular risk. Statins made no difference to dementia or cognitive scores, and the authors thought the earlier promising observational findings reflected indication bias.
- ●Observational studies compare people who happen to take statins with those who do not, and statin users differ in many other ways, so they cannot show cause and effect. NICE NG97 advises against offering statins to slow Alzheimer's disease outside a trial.
- ●The 2024 Lancet Commission added high LDL cholesterol in midlife to its modifiable dementia risk factors, accounting for about 7% of cases, from cohort studies. This supports cholesterol mattering for the brain, but no randomised trial shows that starting a statin in midlife prevents dementia.
- ●Honest summary: a statin may or may not help her brain; it is unproven and not a reason guidance gives for starting one.
- ●Memory loss is an uncommon side effect in the British National Formulary (BNF), usually mild and improving once the statin is stopped (US FDA review, 2012), and NICE found no good evidence that statins cause dementia.
Family History of Dementia and Genetic Testing
- ●Late onset Alzheimer's disease (after 65) results from age, lifestyle, environment and risk genes. Alzheimer's Research UK states that 99 in 100 cases are not directly caused by a gene inherited from a parent. A parent with late onset Alzheimer's raises risk somewhat but does not mean she will develop it. Her mother was diagnosed at 77 and an aunt in her late eighties.
- ●APOE4 increases risk, but many carriers never develop dementia and many without it do. Testing for risk genes is not available on the NHS. Rare inherited forms usually start before 65 across generations, which is the reason for genetics referral. A truthful answer to "Am I going to end up like Mum?" is that her risk is somewhat higher than average, not fixed, and partly modifiable.
Lifestyle for Heart and Brain
- ●NICE NG16 says changes in midlife still bring gains, and the Lancet Commission lists 14 modifiable dementia risk factors, many shared with heart risk.
- ●Alcohol: no more than 14 units a week, spread over three or more days with drink free days. A large 250 ml glass of wine is about 3 units, so five or six a week is 15 to 18 units.
- ●Activity: at least 150 minutes of moderate activity a week plus strengthening on two days. Diet: saturated fat replaced by olive or rapeseed oil; her family cooking is a good base, and the halloumi, biscuits and takeaway are the targets. Weight: gradual loss from a BMI of 28.6. Blood pressure: 136/84 is below the hypertension threshold, but recheck it.
Starting Atorvastatin Safely and Monitoring
- ●Baseline: lipids, HbA1c, renal function and a liver transaminase (ALT), plus thyroid function only if there are symptoms. Her health check covered lipids and HbA1c, so she needs ALT and renal function. Treat secondary causes such as alcohol excess.
- ●Statins are contraindicated in pregnancy. Women aged 50 or over using non hormonal contraception can stop it after 12 months without a period (Faculty of Sexual and Reproductive Healthcare). Her last period was four months ago, so she counts as potentially fertile, but her husband's vasectomy covers this.
- ●Warn that grapefruit juice, some other medicines and some supplements interfere with statins. The BNF lists no interaction with omega 3. The MHRA (2023) warns of rare new or worsened myasthenia gravis.
- ●Repeat lipids and ALT at 2 to 3 months, aiming for a fall of over 40% in non HDL cholesterol, from 5.2 to about 3.1 mmol/L or below. Repeat ALT at 12 months, then an annual review.
- ●Advise reporting unexplained muscle pain, tenderness or weakness (check creatine kinase). Severe pain or weakness, especially with dark urine, needs same day assessment. Report worsening weakness, double vision, drooping eyelids or swallowing difficulty, with 999 for severe breathing or swallowing problems. Stop and call if pregnancy is possible.
Things Not to Offer, and Supporting Her as a Carer
- ●Do not offer omega 3 fish oil to prevent cardiovascular disease, because there is no evidence it helps (NG238). Do not routinely offer aspirin for primary prevention, as bleeding risk offsets benefit.
- ●Stella visits her mother most evenings after a full working day. The difficulty getting off to sleep and evening wine are signs of strain and grief. Ask how she is coping, screen briefly for depression, record her as a carer, signpost to the Dementia UK Admiral Nurse Helpline and the Alzheimer's Society, and offer a follow up about mood, sleep and drinking.
Common Mistakes in This Station
- ●Discussing cholesterol for 12 minutes without finding out that the request is about dementia.
- ●Refusing a statin because her QRISK3 is under 10%, or insisting she earns it through lifestyle change first.
- ●Prescribing with a promise, stated or implied, that it will protect her memory, or brushing the question aside without explaining the evidence.
- ●Giving relative risk reductions only, or no numbers at all.
- ●Counting her father's heart attack at 74 as premature, or offering a genetic test or genetics referral for a late onset family history.
- ●Starting a statin without baseline ALT and renal function, or without asking whether a 50 year old with periods four months ago could become pregnant.
- ●Endorsing fish oils or a daily aspirin.
- ●Generic lifestyle advice that misses her 15 to 18 units of wine a week and the walking and swimming she has stopped.
- ●Treating her only as a cholesterol result and missing a grieving daughter who is caring for her mother.
- ●Safety netting that names no symptoms and no action.
Further reading
From the PCCS Academy, the Primary Care Cardiovascular Society’s learning modules for primary care.
Free for practising healthcare professionals. You need a PCCS account to open these. Join the PCCS
Mapped to the RCGP curriculum topic: Cardiovascular Health.
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