HRT After a Past Blood Clot — Free SCA Practice Case
Woman with a past blood clot asking whether HRT is safe for her
Station Timer
Golden Minute
Initial Introduction
•Introduce yourself
•Ask an open question — "How can I help you today?"
•Listen — don't interrupt
•Catch early cues
Data Gathering
History, ICE & Diagnosis
Clinical Management
Diagnosis, Plan & Decisions
Safety Net
Follow-up & Close
Five cases are free: a live 12-minute consultation with an AI patient each, marked, and no card.
Materials for Candidate
Please review before starting the consultation
Full Name
Ruth Abernethy
Age
51 years
Consultation Type
VideoAge
51
Situation
Video Consultation. Routine appointment booked by the patient.
Reason for Encounter
"Night sweats and poor sleep for months. Would like to discuss HRT. Has had a blood clot in the past."
Medical Records
- ●PMH: Left leg deep vein thrombosis, 8 years ago.
- ●Medications: None.
- ●Allergies: NKDA.
- ●Social: Non smoker.
Recent Notes
- ●Anticoagulation clinic letter, 8 years ago: Left popliteal DVT four days after a long haul flight. No pulmonary embolism. Rivaroxaban for 3 months, then stopped. Attributed to travel. Thrombophilia testing not indicated.
- ●Practice nurse, 2 months ago: Cervical screening HPV negative. BP 124/78, BMI 27.2.
Patient Script
For the friend playing the patient role
Character Overview: You are Ruth Abernethy, a 51 year old senior archivist at the county records office, where you have worked for twenty two years. You live with your wife Lorna, a bus driver on early shifts. You have no children. You are on this video call at your kitchen table.
The night sweats and hot flushes began soon after your periods started to change, and you now sleep four or five broken hours. For four or five months you have felt low, tearful and short tempered. Your periods became irregular a year ago and the last was about four months ago. You had read that HRT is the thing that works.
Eight years ago, aged 43, you had a blood clot in your left leg four days after flying home from visiting your brother Dougie in Perth. You thought you had pulled a calf muscle and only went to A&E when the whole leg swelled up. You took blood thinners for three months, then the clinic stopped them, saying the flight had caused it. Your friend Carys from work, who had a clot on her lung, says her doctor told her HRT was out of the question and that it will be the same for you. You believe any hormone makes your blood sticky, and you assume HRT means a daily tablet. You know nothing about patches or gels.
You are dry humoured and organised, but worn out. Your voice is flat and tired, and wobbles when you talk about crying in the car before work. You do not volunteer your low mood, your fear of missing another clot, or your plan to ask for sleeping tablets until asked.
Opening Sentence: "Hello, thanks for fitting me in. I've had night sweats for months now and I'm hardly sleeping. I wanted to ask about HRT, but I had a blood clot in my leg years ago, and a friend of mine says that means HRT's completely out of the question for me. Is she right?"
History if Asked (Data Gathering Phase)
- ●The night sweats and flushes: "They started soon after my periods began to go all over the place, and they've got worse since. Most nights now. I wake up three or four times wet through, pyjamas soaked, and I have to get up and change. Lorna's started putting a towel on my pillow. In the day it's six or eight flushes, a wave of heat up my chest and face, then I go cold and clammy. It's mortifying at work."
- ●Sleep: "Four or five hours, in bits. Some nights I go to the spare room so I don't wake Lorna."
- ●Periods: "They went all over the place about a year ago. Six weeks apart, then ten weeks, and lighter. The last was about four months ago. No bleeding between periods or after sex. Contraception's never come into it, I'm married to Lorna."
- ●Mood (if asked): "Honestly, low. For the last four or five months. Tearful over nothing and short with everyone. It's always worse after a bad night. When I've slept I still love my Saturday pottery class and my walks along the canal. I'm just too shattered to do any of it." No hopelessness and no thoughts of harming herself: "I'm fed up, not hopeless." No past mental health problems: "I've always been the steady one."
- ●What happened with the clot (if asked): "I flew home from Perth and my calf ached, and I thought I'd pulled something lugging the suitcase. Four days later my whole leg swelled up and Lorna marched me to A&E. It was a clot behind my knee. It hadn't gone to my lungs. Blood thinning tablets for three months, then they stopped them. They said it was down to the flight."
- ●Since then, hormones and family (if asked): "Nothing since. My leg's been fine for years. I haven't done a long flight since. I've never been on the pill or any hormones. No clotting tests, they said I didn't need any. Nobody in the family has had a clot."
Ideas, Concerns, Expectations
Gating note: Ruth raises none of the following herself. Each part comes out only when the doctor asks what she thinks is going on, what is worrying her, or what she was hoping for.
- ●Ideas: She puts the symptoms down to her age and hormones, believes the friend's warning applies to her, and assumes HRT is a daily tablet. "I assume it's my age. But Carys at work had a clot on her lung, and her doctor told her flat out she couldn't have HRT. She says any hormones make your blood sticky, so it'll be the same for me." If asked what she knows about HRT: "Only that it's a daily tablet."
- ●Concerns: Her first worry is another clot. "That clot frightened the life out of me. I walked around on it for four days thinking I'd pulled a muscle. If I had another one, I'm not sure I'd spot it." If the doctor explores further, her voice wobbles and a second worry comes out: "And my fuse has got frighteningly short. I've cried in the car before work twice this month. My manager had a quiet word because I was sharp with a researcher. In twenty two years that's never happened."
- ●Expectations: She half expects to be told no. "If HRT's off the table, I was going to ask for some sleeping tablets, just to get me through. But if there's a safe way to have it, I'd want to hear it."
If Asked: Medical History and Medications
Gating note: Ruth answers each of these plainly when asked.
- ●General health: "I'm usually healthy. Nothing regular, the odd paracetamol. No allergies. Nothing tried for the sweats except a fan and the window open."
- ●Breast, heart and other conditions: No lumps, and her first mammogram last year was clear. No breast or ovarian cancer in the family. No migraines, heart problems, stroke, liver problems or high blood pressure.
- ●Smear, operations and flights: Smear two months ago, normal. No operations planned and no long flights booked.
Social History and Lifestyle Impact
- ●Work and home: Runs the public reading room two days a week and covers one late opening evening. "I've missed my pottery class the last three Saturdays, and I've started dreading the late evening at work."
- ●Alcohol (if asked): "I've got into the habit of a large glass of white wine most nights to help me drop off. Five nights a week, probably." If asked how big: "The big ones, 250 mils." If asked whether it helps: "I fall asleep quicker, but I'm awake and soaked in the early hours."
- ●Other: Three coffees a day, the last mid afternoon. Never smoked. Has put on half a stone this year.
If Asked: Associated Symptoms
Gating note: Answers are brief. The following are all negative: weight loss, fevers or shivering ("it's heat coming in waves, not a fever"), lumps in her neck, armpits or groin, cough, breathlessness, chest pain, a racing heart or shakiness, pain or swelling in her legs now, vaginal dryness, pain with sex or passing water, new medicines.
Responses to Management (The Negotiation Phase)
- ●If the doctor explains that HRT is not automatically ruled out and that oestrogen through the skin differs from tablets, or suggests tablets:
- ●Reaction: Surprised, relieved. "So it's not a straight no? Then why was Carys told she couldn't have it?" She settles if told her friend's clot or HRT may have been different. If tablets are suggested: "Would a tablet be safe with my clot? That's exactly what I was scared of."
- ●If the doctor wants specialist advice before starting, or offers to prescribe today and mentions the leaflet lists a past clot:
- ●Reaction: Worried about the wait. "How long will that take? I'm not sure how many more nights like this I can do." She accepts a rough timescale and something to help meanwhile. On the leaflet: "So it'll say I shouldn't be taking it? That's a bit alarming." She goes ahead if told why the doctor is comfortable, how she will be followed up, and that she can stop any time.
- ●If the doctor explains she needs a second hormone to protect her womb, suggests a hormone coil, mentions a monthly bleed, or discusses breast cancer risk:
- ●Reaction: "Another hormone? Does that one make clots more likely too?" Reassured if told which options are least likely to. On the coil: "A coil? I'm married to a woman, I don't need contraception." Once explained: "I'd want to think about which I'd prefer." On a bleed: "So my periods come back? I thought I was nearly done with them." On breast cancer: "How much does it actually go up?"
- ●If the doctor raises the wine, declines or offers sleeping tablets, or suggests an antidepressant, talking therapy or a non hormonal tablet:
- ●Reaction: On the wine, a little defensive: "It's the only thing that gets me off to sleep." If told it can bring on flushes and wake her later: "That would explain waking up soaked in the early hours. I'll try cutting it down." If sleeping tablets are declined: "So I just keep not sleeping?" She accepts if told treating the sweats should help her sleep. On an antidepressant: "I'm not depressed, I'm exhausted." On talking therapy: "How does talking stop me sweating?" She will try it if told it helps with coping. On a non hormonal tablet: "What's the catch?"
- ●If the doctor suggests blood tests for her hormones or clotting, or asks to look at her leg on camera:
- ●Reaction: "Do I need to wait for those before anything happens? Would a clotting test change what you'd do?" Declines a leg check politely: "I'd rather not on video, the leg's been fine for years. I can come in."
- ●If the doctor gives vague safety netting, explains the warning signs of a clot, or agrees a plan:
- ●Reaction: Vague: "But that's the problem, I didn't know last time. What would actually tell me it's a clot, and what do I do?" Once explained: "So a swollen, painful calf, I get seen that day. I wish I'd known that." Once a plan is agreed: "Is this going to go on for years? Am I on HRT for life?"
Mark Scheme
Domain 1: Data Gathering and Diagnosis
Domain 2: Clinical Management and Medical Complexity
Domain 3: Relating to Others
Clinical Learning Points
The Core Dilemma and the Model Plan
- ●Ruth, 51, has perimenopausal flushes, sweats and low mood and wants HRT, but had a leg clot 8 years ago and believes, from a friend, that she is ruled out. The skill is to avoid a blanket "no" or an automatic oral prescription: a past clot does not rule out HRT, the route of oestrogen decides most of the risk, and the licence position and her fears need explaining.
- ●Model answer: diagnose perimenopause clinically; explain that oestrogen through the skin differs from tablets; tell her a past clot is a listed contraindication, so HRT would be outside the licence; seek advice from a menopause specialist or haematologist before starting; plan transdermal oestrogen with micronised progesterone or a levonorgestrel coil; cover mood, alcohol and a fallback; give clot warning signs; review.
- ●Also acceptable: a GP who confirms a single, fully treated, travel associated clot, explains the licence position, records her agreement and starts transdermal oestrogen with early review.
Recognising the Perimenopause Without Blood Tests
- ●NICE NG23 advises identifying perimenopause without laboratory tests in otherwise healthy people aged 45 or over with vasomotor symptoms and a change in their cycle. Hormone tests are reserved for ages 40 to 45 with symptoms, or under 40 when premature ovarian insufficiency is suspected.
- ●Ruth's sweats and flushes began soon after her periods became irregular and lighter about a year ago. A brief check for weight loss, fever, lumps, cough, thyroid symptoms and new medicines is proportionate. Ask about bleeding: a sudden change, bleeding between periods or after sex needs assessment.
- ●Contraception is part of most perimenopause consultations, because HRT is not contraceptive. It does not arise for Ruth, who is married to a woman.
Why the Route of Oestrogen Matters, and Classifying Her Clot
- ●Oral oestrogen passes through the liver first and increases clotting factors. The British Menopause Society (BMS) states that oral HRT increases venous thromboembolism (VTE) risk two to four fold, most in the first year, and that route is the most important determinant. NG23 says VTE risk is not increased with transdermal HRT. Micronised progesterone and dydrogesterone are unlikely to raise risk; medroxyprogesterone acetate was associated with higher risk.
- ●Tibolone is taken by mouth and is not suitable here: the BNF lists VTE as a contraindication, and it should not be started within 12 months of the last period.
- ●NICE NG158 defines a provoked DVT as one within 3 months of a major transient risk factor such as surgery, trauma, pregnancy or hormones. A flight is not among them, so Ruth's clot sits between provoked and unprovoked. Features that make her lower risk: a single event with a clear trigger, no lung clot, completed treatment, no recurrence in 8 years, no hormones at the time, no family history, BMI 27.2, no smoking.
- ●NG158 advises against thrombophilia testing after a provoked VTE. Ordering a screen as a condition of HRT adds delay without changing the plan, and the BMS says routine testing before HRT is unnecessary.
HRT After a Past Clot and Prescribing Outside the Licence
- ●NG23 advises considering transdermal HRT for people at increased VTE risk, referral to a haematologist before HRT for those at high risk, and referral to a clinician with menopause expertise where there is a contraindication or uncertainty.
- ●The BNF lists a history of VTE as a contraindication to estradiol and a history of thromboembolism for progesterone. NICE Clinical Knowledge Summaries (CKS) refer to idiopathic VTE as a contraindication and other predisposing factors as cautions. Either way the leaflet will list her clot, so prescribing is outside the product licence and she should be told so.
- ●The General Medical Council (GMC) allows off label prescribing where an individual assessment shows it is necessary, with enough information for an informed decision and the reasons recorded. Telling her beforehand prevents alarm at the leaflet.
- ●The BMS states that in women with a past VTE, transdermal oestrogen with micronised progesterone is unlikely to raise risk above her own, and that haematology discussion should be considered when risk is particularly high. Practice varies, so either specialist advice first or an informed start by the GP is acceptable.
Choosing the Regimen
- ●Oestrogen: transdermal estradiol as a patch, gel or spray, starting low and adjusting at review.
- ●Progestogen: she has a womb, so she needs one. Because her last period was under a year ago, a sequential regimen is used, the progestogen for 12 to 14 days a month, with micronised progesterone 200 mg at bedtime for 12 days (BNF) or dydrogesterone 10 mg for 14 days. A monthly withdrawal bleed is expected.
- ●A 52 mg levonorgestrel intrauterine device gives local endometrial protection with low systemic levels and reduces unscheduled bleeding. Women over 45 on sequential HRT should be offered a switch to continuous combined HRT after 5 years or by age 54.
The Other Benefits and Risks to Share
- ●HRT is the most effective treatment for vasomotor symptoms, may improve sleep and depressive symptoms that began with the menopause, and reduces fragility fracture risk while taken.
- ●Combined HRT increases breast cancer risk; the increase rises with duration, is higher in current users and declines after stopping. Sequential regimens carry a lower risk than continuous combined ones (NG23). The BMS notes that drinking two or more units a day is associated with a greater breast cancer risk than 5 years of combined HRT. Ruth's 15 units a week averages two units a day.
- ●Stroke risk is unlikely to rise with transdermal oestrogen. Review at 3 months, then at least yearly. There is no arbitrary limit on duration.
Low Mood, Sleep and the Wine
- ●NG23 advises considering HRT for depressive symptoms that do not meet the criteria for depression and began with other menopause symptoms, and menopause specific cognitive behavioural therapy (CBT). A focused assessment covers duration, enjoyment, past depression and direct questions about self harm.
- ●There is no clear evidence that SSRIs or SNRIs improve low mood in menopausal women without depression, so they are not first line. Ruth's mood tracks her broken nights, so treating the sweats and sleep is the most direct route.
- ●Evening alcohol shortens the time to fall asleep but fragments the second half of the night, which fits waking soaked in the early hours. Sleeping tablets do not treat night sweats and are for short courses only.
Non Hormonal Options if HRT Is Unsuitable or Declined
- ●Fezolinetant 45 mg once daily is recommended by NICE (TA1143) for moderate to severe vasomotor symptoms when HRT is unsuitable. The MHRA requires liver function tests before starting, monthly for 3 months and periodically after.
- ●SSRIs, SNRIs and clonidine are not routine first line for flushes alone, but they and gabapentin are options when HRT is unsuitable, mostly off label. Practical measures: a cool bedroom, layers, less caffeine and alcohol, and menopause specific CBT.
Safety Netting and Follow Up
- ●Clot warning signs, specifically because she missed the first clot for four days: a painful, swollen, warm or discoloured calf needs assessment the same day; sudden breathlessness, chest pain or coughing up blood needs 999.
- ●Bleeding: some unscheduled bleeding is common in the first 6 months of HRT; heavier or longer bleeding, or bleeding beyond that, should be reported. Thoughts of self harm need help the same day.
- ●Contact her when specialist advice returns, or check early if HRT starts now; review at 3 months for symptoms, bleeding, blood pressure, weight and mood, then at least yearly. Encourage continued breast and cervical screening.
Common Mistakes in This Station
- ●Agreeing with the friend that a past clot rules out HRT without considering oestrogen through the skin or specialist advice.
- ●Prescribing oral HRT, combined tablets or tibolone as the usual first prescription.
- ●Starting transdermal HRT without mentioning that a past clot is a listed contraindication, so she is alarmed by the leaflet.
- ●Prescribing oestrogen alone for a woman who still has her womb.
- ●Ordering a hormone test to confirm the menopause, or a thrombophilia screen as a condition of treatment.
- ●Offering an antidepressant first line, or a sleeping tablet for night sweats.
- ●Not asking about self harm, or missing the nightly wine.
- ●Safety netting with "come back if you're worried" when she did not recognise her first clot, or telling her HRT must stop after five years.
Further reading
From the PCCS Academy, the Primary Care Cardiovascular Society’s learning modules for primary care.
Free for practising healthcare professionals. You need a PCCS account to open these. Join the PCCS
Mapped to the RCGP curriculum topic: Gynaecology and Breast.
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