Schizophrenia Who Wants to Stop His Antipsychotic Because of Weight Gain — Free SCA Practice Case
Man with schizophrenia who wants to stop his antipsychotic because of weight gain
Station Timer
Golden Minute
Initial Introduction
•Introduce yourself
•Ask an open question — "How can I help you today?"
•Listen — don't interrupt
•Catch early cues
Data Gathering
History, ICE & Diagnosis
Clinical Management
Diagnosis, Plan & Decisions
Safety Net
Follow-up & Close
Five cases are free: a live 12-minute consultation with an AI patient each, marked, and no card.
Materials for Candidate
Please review before starting the consultation
Full Name
Jamal Osborne
Age
45 years
Consultation Type
VideoAge
45
Situation
Video Consultation.
Reason for Encounter
"Wants to talk about coming off olanzapine because of weight gain."
Medical Records
- ●PMH: Schizophrenia, diagnosed about 20 years ago. One admission, 2 years ago. Under the community mental health team.
- ●Medications: Olanzapine 15 mg at night since discharge.
- ●Allergies: NKDA.
- ●Social: Stock controller. Lives with partner.
Recent Notes
- ●Health check, 6 weeks ago (nurse): Weight 101 kg (82 kg at discharge), BMI 31.9, BP 132/84. HbA1c 44 mmol/mol. Non HDL cholesterol 4.3 mmol/L.
- ●Psychiatrist letter, 2 months ago: Stable, no risk concerns. Olanzapine continued. Review in 4 months.
Patient Script
For the friend playing the patient role
Character Overview: You are Jamal Osborne, a 45 year old stock controller at a builders' merchant. You live in a rented flat with your girlfriend Keisha, a bookkeeper, together about eighteen months. About twenty years ago, in your mid twenties, you were diagnosed after you started hearing voices. You never use the name of the diagnosis; you say "my mental health" or "what I was diagnosed with". In the years after that you were on risperidone, which you took only when you remembered. Just over two years ago, after losing your job and your flat, you stopped sleeping and ended up in hospital for six weeks, your only admission. Olanzapine was started there and you have taken 15 mg at night ever since, every night, without missing one. You have been well since and you are back at work. But you have put on three stone and it is all you think about. A health check six weeks ago shook you, and you have decided to stop the tablets tonight. You have told nobody, and you are sure you are well enough not to need them. You are friendly and quick with a joke, but you bristle if you feel lectured or managed, and you are quietly ashamed of your weight. Your voice drops when you talk about how you look and gets brisker when someone seems to be telling you what to do.
Opening Sentence: "Hi doctor. I want to come off the olanzapine, tonight if I can. I've put on three stone since I started it and I can't take it any more. I've been fine for ages, so I don't see why I still need it."
History if Asked (Data Gathering Phase)
- ●The weight gain: "About three stone in two years. I was just under thirteen stone when I came out of hospital and now I'm nearly sixteen. Most of it went on in the first year." Hungry all the time, even straight after tea. Some nights he gets up in the early hours and eats cereal or toast, then feels disgusted with himself. He tried a gym and fewer takeaways for a few months: "I lost a bit, then it all came back. It feels like the tablets, not willpower."
- ●What it has done to him (if asked): "None of my trousers fit, I've stopped swimming and I avoid the pub quiz because everyone will comment. Keisha says she doesn't mind, but I mind."
- ●How he takes it and why he wants to stop now (if asked how he takes it, whether he misses any, why now, or what made him decide): "Every night, last thing, with a glass of water. I've not missed one since I came out of hospital, not one. That's why I know it's the tablets making me fat, I've done everything right." If asked why now: "The health check. The nurse put me on her scales and I saw a hundred and one, then she said my sugar was a bit high. I came out of that surgery and thought, that's it, I'm done." He plans to stop completely tonight and has not tried going without them.
- ●Whether his team knows (if asked): "No. Kirsty, my care coordinator, would just tell me not to. I haven't told the psychiatrist either. I'm not seeing him for a few months."
- ●The last time he was ill (if asked): "Just over two years ago. I'd been on risperidone but only took it when I remembered. I'd lost my job and flat, I was drinking loads and smoking weed. I stopped sleeping, a few nights with nothing at all. Then I heard a man's voice commenting on everything I did, like a running commentary. Six weeks in hospital." The sleep went first, then he stopped eating. Keisha says she would spot it now.
- ●How he is now (if asked about voices, strange thoughts, sleep, mood or harm): "No voices, nothing like that. Nobody's out to get me. I sleep about eight hours, if anything too much. I'm fed up about the weight but I'm not low and I still enjoy things. I'd never hurt myself or anyone."
- ●Drink and drugs (if asked): "Three pints on a Saturday. I haven't touched weed since I came out of hospital."
Ideas, Concerns, Expectations
Gating note: Jamal raises none of this himself. Each part comes out only when the doctor asks what he thinks is behind the weight or the tablets, what is worrying him, or what he was hoping for today.
- ●Ideas: He believes the olanzapine has done this and that once he is off it the weight will drop and he will be himself again. He thinks he has been well so long that he is "better". Last time was different, he says, because he was not taking the risperidone properly and was drinking and smoking. "I reckon it's the tablets, one hundred percent. Last time I was a mess and I wasn't taking them properly. I've taken every single one since, so it's not the same."
- ●Concerns: His main worry is turning into his dad. At the health check the nurse said his sugar was a bit high and all he could think of was his dad. If the doctor explores further, a quieter fear emerges: he does not want to go back into hospital, but he is more scared of being fat and stuck on tablets for years. "I'm forty five and I'm going the same way."
- ●Expectations: He hopes to be told stopping is fine, or at least to be listened to and not lectured. "If you say I can't, I'll probably just stop anyway."
If Asked: Medical History and Medications
Gating note: Jamal answers each of these plainly when the doctor asks about it.
- ●Health and medicines: No other health problems, medicines or supplements. No allergies. Never smoked.
- ●Effects of the olanzapine: "Tired in the mornings, a bit slow first thing." No shakes, stiffness or restlessness. No thirst or night time urine. No palpitations, fainting or breast changes. If asked sensitively about sex: "I'm not as interested as I used to be and things take longer."
- ●The health check (if asked): "The nurse said my sugar was borderline and gave me a leaflet. Nobody's followed it up."
- ●Family history (if asked): "Dad's got type 2 diabetes. He was diagnosed in his early fifties, he's on injections now and he's lost some feeling in his feet."
Social History and Lifestyle Impact
- ●Work and home: Has missed no work through illness since hospital. Keisha knows about the illness and the admission and is supportive. "She'd notice if I wasn't right."
- ●Food and activity: "Takeaway about twice a week. Two cans of cola at work most days. I eat big portions and I'm still hungry." He walks twenty minutes to work. He used to swim.
- ●Crisis plan (if asked who would notice, or whether he has a plan): Keisha would spot the sleep change straight away. "Kirsty gave me a card with the crisis number but I've not looked at it for ages."
Responses to Management (The Negotiation Phase)
- ●If the doctor says stopping suddenly is not a good idea, or that feeling well for two years on the tablet does not prove he would stay well without it:
- ●Reaction: Defensive but listening. "I've taken it every night for two years and I've been well. It's not the same as last time, I wasn't taking the risperidone properly and I was drinking and smoking weed." If the doctor acknowledges that, including how reliably he has taken it, and explains why the risk is still real, he softens: "So even if I'm fine now, I could go wrong in a few weeks? That's really annoying." If the doctor warns he will end up back in hospital: "So I'm stuck with it and getting fatter? I'll probably just stop anyway." He engages again if asked what would make him hold off.
- ●If the doctor suggests contacting his care coordinator or psychiatrist:
- ●Reaction: Wary. "They'll just tell me to take it. Kirsty always says give it time." If told the call is to ask about alternatives and he will hear what comes back: "Okay. Would you ring them? I'd rather you did." If it is done without asking him: "You're going behind my back?" He asks, "When do I hear back? I don't want it hanging for weeks," and "So what do I do tonight, take it?" If told to take it as usual while the team is contacted and a review is booked within days: "If it's days and not months, I can do that. But I'm not signing up for years without a plan."
- ●If the doctor offers ways to tackle the weight (a switch, a slower reduction, metformin or an injection):
- ●Reaction: Interested in a switch. "Would I actually lose the weight? How long does a swap take? Will I feel rough?" If told weight loss is not guaranteed: "Fair enough. At least that's a straight answer. I just want a chance." On metformin: "Isn't that a diabetes tablet?" He accepts it once told the specialist would need to agree.
- ●If the doctor explains his blood test, or suggests a lifestyle or weight programme:
- ●Reaction: Anxious. "So have I got diabetes?" Relieved if told it is a warning range, not diabetes, that it can come down and his dad's diagnosis is the reason to act now: "So it's not too late." On a programme: "I've done the gym. Is it a group? I don't want a room full of strangers looking at me." He is open if told it is tailored and that night hunger is a known effect of olanzapine: "So it's not just me being greedy?"
- ●If the doctor asks about involving Keisha, or how long he would need tablets:
- ●Reaction: "She'd help. Just let me tell her myself." On duration: "How many more years are we talking? Is there any way off them?" He accepts a straight answer: nobody can say for certain, it is usually years, it is reviewed yearly, and any reduction would be slow and done with the team.
- ●If the doctor gives vague safety netting, leaves it as his choice, or threatens to stop prescribing:
- ●Reaction: On vague advice: "Worse how? What am I looking out for? What do I do if I can't sleep and it's the middle of the night?" He wants specific signs and a named number. If left to decide alone: "So I just stop tonight and nobody checks on me? That doesn't feel right either." If prescribing is threatened: "Right. So I'll just not collect it then." He stays on the call if told the prescription will continue while a plan is agreed.
Mark Scheme
Domain 1: Data Gathering and Diagnosis
Domain 2: Clinical Management and Medical Complexity
Domain 3: Relating to Others
Clinical Learning Points
The Dilemma and the Model Plan
- ●Jamal is a capable adult, well for two years, with a real and distressing side effect: three stone of weight gain. He has taken olanzapine every night since discharge, plans to stop tonight because of how he looks and what the health check showed, and has told no one. His main fear is following his father into type 2 diabetes.
- ●The task is not to win an argument. It is to keep him well and engaged, and to treat the weight and blood sugar as problems in their own right. Done well, the weight gain becomes the reason to review the medicine, not the reason to abandon it.
- ●Model plan: take his reason seriously, check his mental state, how he takes the tablet and why he wants to stop now, advise against stopping suddenly, agree that he takes tonight's tablet while the team is contacted within days, ask the psychiatrist or care coordinator for an early medication review, start the physical health work that belongs in primary care, agree a specific relapse plan, and review in person in one to two weeks.
- ●Acceptable alternatives: a team agreed gradual reduction, a switch to a drug less likely to cause weight gain, or lifestyle support alone, all decided with the psychiatrist. The GP does not switch or reduce the antipsychotic alone in this consultation.
Why Stopping Suddenly Is Risky
- ●The British National Formulary (BNF) says relapse risk is high if antipsychotics are stopped after 1 to 2 years. Withdrawal after long term treatment should always be gradual and monitored, to avoid acute withdrawal syndromes or rapid relapse, with monitoring for 2 years afterwards.
- ●NICE CG178 (Psychosis and schizophrenia in adults) makes the same points for the early post acute period. Jamal is 2 years from admission, so it does not apply word for word, but he has had a relapse after lapses in taking his medicine, which makes the BNF advice the better basis.
- ●Two years of feeling well while taking the tablet every night shows it is working, not that he no longer needs it. Relapse can appear weeks or months after stopping. Stopping tonight would be an abrupt, unmonitored withdrawal.
- ●NICE Clinical Knowledge Summaries (CKS) add that dose should not be cut below the standard range during maintenance, which is one reason any reduction is the psychiatrist's decision and may be modest. Targeted or intermittent dosing is not routinely recommended and is a specialist decision.
Olanzapine, Weight and Appetite
- ●Olanzapine commonly causes weight gain, increased appetite, drowsiness and hyperglycaemia, and has a higher prevalence of sexual dysfunction (BNF). Constant hunger and night eating are therefore understandable, and telling him so changes how he hears every piece of lifestyle advice.
- ●The BNF lists amisulpride, asenapine, aripiprazole, cariprazine, haloperidol, lurasidone, sulpiride and trifluoperazine as least likely to cause weight gain. Usual olanzapine dose is 5 to 20 mg daily, so his 15 mg is within range and a dose that is simply too high is not the explanation.
Options When He Wants Off Olanzapine Because of Weight
- ●Specialist review. CG178 (1.5.3.7 and 1.5.3.8) recommends considering referral back to secondary care for intolerable side effects or non adherence. CKS advises specialist review if adherence is poor or effects are poorly tolerated.
- ●Switch to a drug less likely to cause weight gain, chosen by the psychiatrist, done gradually, with relapse watched for. A switch is not guaranteed to reverse weight gain and the new drug may suit him less. Be honest about both.
- ●Planned slow reduction if the psychiatrist agrees.
- ●Lifestyle programmes. CG178 (1.1.2.1) recommends a combined healthy eating and activity programme for people on antipsychotics.
- ●Metformin is an optional extra, never a required step. It is off label for this purpose and usually agreed with the specialist. A 2025 Schizophrenia Bulletin guideline found it the only drug with demonstrated efficacy for preventing antipsychotic weight gain. The British Association for Psychopharmacology guideline (2016) says metformin should be considered to reduce antipsychotic weight gain once lifestyle measures have been fully explored, with monitoring of kidney function and vitamin B12.
- ●A long acting injection (CG178 1.5.5.3) suits those who would prefer it or where avoiding covert non adherence is a clinical priority. Neither applies here, as he has taken his tablets reliably, and it does not solve weight gain.
Physical Health Monitoring and His HbA1c
- ●CG178 (1.3.6.4) sets weight, waist, pulse, blood pressure, glucose or HbA1c and lipids at 12 weeks, at 1 year and then annually. The BNF advises more frequent weight and lipid checks for olanzapine, every 3 months in the first year. Primary care does a full annual check and copies results to the care coordinator and psychiatrist (CG178 1.5.3.2).
- ●His 101 kg and 178 cm give a BMI of 31.9, in the obesity range, about 19 kg (3 stone) above his discharge weight. Lipids do not need a drug decision here but should be tracked.
- ●NICE PH38 defines an HbA1c of 42 to 47 mmol/mol as high risk of type 2 diabetes. Diabetes is diagnosed from 48. His 44 is therefore a warning that can come down with weight loss, which is the honest and hopeful message. Nobody can promise he will avoid diabetes.
- ●PH38 advises at least annual testing, lifestyle review and an intensive lifestyle programme such as the NHS Diabetes Prevention Programme (check local referral rules) or a local weight management service. The nurse booked no follow up, so closing that loop is part of the task.
- ●Weight, waist and blood pressure cannot be measured over video. He has no scales, so arrange an in person check.
Working With the Mental Health Team
- ●Telephone the care coordinator or psychiatrist the same day or next working day, because he intends to stop tonight. Up to about a week is acceptable if an interim plan is agreed. No guideline gives a number of days. Ask for a review sooner than the routine one in four months, and give the weight trajectory, the HbA1c and his plan.
- ●Continue prescribing olanzapine while the plan is agreed. Withholding it risks an unmonitored abrupt stop.
- ●Ask his permission, tell him what will be shared and say the call is to ask about alternatives, since he fears being talked out of his view.
If He Still Wants to Stop
- ●He is presumed to have capacity (Mental Capacity Act 2005) and is well, so there is no basis for compulsion. Mentioning compulsory treatment or admission as a threat is inaccurate and damages trust.
- ●Aim for the safest version of his choice: gradual reduction agreed with the psychiatrist over weeks to months, monitoring for relapse for at least 2 years after any withdrawal, Keisha as an informed observer if he agrees, and a way back to the tablet or the team without judgement. Document the advice and his understanding of the risk.
Relapse Plan and Safety Netting
- ●Build it from his own story: sleep going first, then a voice commenting on his actions, then not eating and snapping at people. On the first sign he tells Keisha, rings the care coordinator or the crisis number on his card, contacts the practice the same day, or uses NHS 111 and the mental health option. He calls 999 if he or anyone is in immediate danger.
- ●The plan holds even if he later cuts down or stops the tablets. Ask him to find his crisis card. A specific plan answers his question: "Worse how, and who do I ring in the middle of the night?"
Communication Points
- ●Start with his problem: "Three stone in two years is a lot, and it makes sense that you blame the tablet."
- ●Use his own account. Last time he was drinking and not taking tablets properly. Both are true, and the risk is still high.
- ●Answer what he asks: "What do I do tonight?" needs a clear answer and "how long on tablets?" needs honest uncertainty.
- ●When he says he will stop anyway, ask what would make him willing to agree a plan. Ask permission before contacting the team or Keisha.
Common Candidate Mistakes in This Station
- ●Agreeing to stop, or telling him to stop, because he has capacity and is well.
- ●Refusing to discuss change, or saying he will be on the tablet for life.
- ●Leaving the medication question to the routine review in four months.
- ●Switching or reducing the dose before the team has advised.
- ●Never asking why he wants to stop now, so the health check that triggered it is missed, or assuming he has been missing doses when he has not.
- ●Not checking mental state, sleep or alcohol first.
- ●Treating an HbA1c of 44 as diabetes, as normal, or doing nothing.
- ●Generic eat less and move more advice, with no programme and no recognition of olanzapine's effect on appetite.
- ●Threatening readmission or compulsory treatment.
- ●Contacting the team or Keisha without his agreement.
- ●Safety netting limited to come back if you feel worse.
Mapped to the RCGP curriculum topic: Mental Health.
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