Lung Cancer Whose Morphine Is Making Him Drowsy and Muddled — Free SCA Practice Case
Man with lung cancer whose morphine is making him drowsy and muddled
Station Timer
Golden Minute
Initial Introduction
•Introduce yourself
•Ask an open question — "How can I help you today?"
•Listen — don't interrupt
•Catch early cues
Data Gathering
History, ICE & Diagnosis
Clinical Management
Diagnosis, Plan & Decisions
Safety Net
Follow-up & Close
Five cases are free: a live 12-minute consultation with an AI patient each, marked, and no card.
Materials for Candidate
Please review before starting the consultation
Full Name
Alasdair Dunmore
Age
72 years
Consultation Type
TelephoneSituation
Telephone Consultation. Moira rings about her husband, who is at home.
Reason for Encounter
"Since his morphine went up he's so sleepy and muddled, and seeing things."
Medical Records (Alasdair Dunmore)
- ●PMH: Stage 4 lung adenocarcinoma, rib and spinal metastases (6 months). COPD. Hypertension.
- ●Medications: Morphine MR 45 mg bd (30 mg bd until 6 days ago). Morphine solution 5 mg prn. Senna 15 mg nocte. Paracetamol 1 g qds. Ramipril 5 mg od.
- ●Allergies: NKDA.
- ●Social: Retired. Lives with wife.
- ●U&E 5 weeks ago: Creatinine 111, eGFR 61.
Patient Script
For the friend playing the patient role
Character Overview: You are Moira Dunmore, a 70 year old retired school secretary, ringing about your husband Alasdair, who is 72. You live in a flat near the harbour. Alasdair was a marine engineer, a quiet, independent man who hates being fussed over. Six months ago he was diagnosed with lung cancer that has spread to his ribs and spine. He has chemotherapy at the cancer centre every three weeks. You give him all his tablets from a dosette box and a list pinned to the fridge. Your daughter Fiona lives 40 minutes away and rings every evening. You are capable and polite, at the kitchen table with the bedroom door open. You keep your voice steady, but it wavers when you talk about the doses. You never use the words "toxicity", "overdose" or "kidney failure". You do not name any diagnosis for what is happening, and you cannot say why it has started. You do not examine Alasdair during the call; if asked, you can count his breaths from the doorway and report.
Opening Sentence: "Hello, doctor, thank you for ringing back. It's about my husband, Alasdair Dunmore. He's been dreadfully sleepy and muddled since last night, he says there are people in the corners of the room, and his hands keep jumping. I don't know what to do."
History if Asked (Data Gathering Phase)
- ●Sleepiness: "Drowsy for about three days, but yesterday evening it got much worse. Today he's slept nearly all morning. I can wake him if I speak loudly or touch his arm, he answers, and then he drifts off mid sentence."
- ●Muddle: "He called me by his mother's name this morning and asked what ship we were on. Usually he's sharp as a tack."
- ●Seeing things: "He keeps looking at the corner by the wardrobe and says two small men in caps are standing there. Last night it was people at the foot of the bed. He's puzzled rather than scared, he said, 'Moira, there's nobody there, is there?'"
- ●Twitching: "His hands and arms jerk, mostly as he's dozing off, like a tiny electric shock. Legs a little too. Quick jumps, then it stops. No fits, nothing stiff or shaking for minutes."
- ●Breathing: "A bit snuffly. I counted this morning, about fifteen a minute, no long pauses, lips a normal colour. He's not struggling."
- ●When it started: "It began a few days after his morphine went up, six days ago. A little worse each day, and last night he got confused."
- ●Pain: "His pain has been better since the increase. Before it was six or seven out of ten in his ribs and back, and he'd cry out turning over. Now he says it's a two."
- ●What he takes: "The slow release morphine, a thirty and a fifteen together, twice a day. I tick them off. He's also had the liquid morphine, five milligrams, about four times yesterday and three the day before. Before the increase it was once or twice a day."
- ●Eating and drinking: "Chemotherapy was twelve days ago. He was sick for two days after it, as always, and it's been hard to get anything into him since. Toast, sips of tea, maybe half a cup of squash yesterday. Hardly any proper drink for about three days."
- ●Passing water: "Very little. This morning on the commode it was a small amount, dark like strong tea."
- ●Bowels: "Not for five days. He's missed his senna the last two nights, too sleepy to swallow it. No cramps, and no vomiting since the weekend."
- ●Thirst and tummy: "Very thirsty with a dry mouth, but he won't drink much because he's so tired."
- ●Headache, weakness, speech: "No headache that he's mentioned. His speech is slow because he's drowsy but not slurred, his face looks the same, and he moves both arms and legs."
- ●Fever or chest: "He doesn't feel hot, his cough is no worse, and he hasn't complained of burning when he passes water."
- ●Fall: "No falls. He hasn't been out of bed except to the commode."
- ●New medicines: "No, just what's on the list, nothing from the chemist."
Ideas, Concerns, Expectations
Gating note: Moira does not raise any of the following herself. Each part comes out only when the doctor asks what she thinks is going on, what is worrying her, or what she was hoping for from the call.
- ●Ideas: She thinks the cancer has spread to his head, because he has been muddled and seeing things, and a lady at the cancer centre once mentioned that could happen. At the back of her mind she wonders whether the morphine is doing it, but she is afraid to say so in case someone takes it away. "I thought maybe it's gone to his brain. And I did wonder about the morphine, but I didn't like to say because he needs it, doesn't he?"
- ●Concerns: She is frightened that she gave him too much, because she gave the new doses. She worries that his pain will return if the morphine is lowered, and that he is dying. She is afraid he will be taken into hospital, because he made her promise he would not go back. "Did I do this? I gave him exactly what was written. And I couldn't bear him in agony again. He made me promise, no more hospitals."
- ●Expectations: She hopes someone will come to the house so he is not moved, and wants to know whether to keep giving the tablets. "Can someone come to see him? And should I give him his tablets tonight or not? I don't want to get it wrong."
If Asked: Medical History and Medications
Gating note: Moira answers each of these plainly when the doctor asks about it.
- ●Cancer: "Lung cancer, found six months ago. It's in his ribs and back bones. Chemo every three weeks, next due in nine days. The oncologist said it's not curable but treatable."
- ●Other health problems: "COPD, and his blood pressure is a bit high. Nothing else. No diabetes and no kidney problems that I know of."
- ●Medicines: "Slow release morphine twice a day, liquid morphine when he needs it, senna at night, paracetamol four times a day, ramipril in the morning, and his inhaler. I gave the ramipril this morning."
- ●Allergies: "None."
- ●Support from the palliative team: "Janet, the palliative nurse, visits most weeks. She suggested putting the morphine up. I have her number but haven't wanted to bother anyone."
- ●Plans for his care: "There's a form in the folder. It says he'd like to be at home and not be resuscitated, and that hospital is fine if something can be fixed quickly. But he told me he doesn't want it if it's only the end."
Social History and Lifestyle Impact
- ●Home: A hospital bed is in the bedroom. Moira manages the tablets and the commode but is exhausted, with about four hours of sleep a night.
- ●Family: Fiona could stay tonight if asked.
- ●Before this: Up and dressed most days, doing the crossword by the window, walking to the shop with his stick.
- ●Availability today: Moira is at home all day and could let someone in.
If Asked: Associated Symptoms
Gating note: Moira answers these only when asked. Every one is negative unless stated.
- ●If asked about a swollen tummy or a full bladder: "He doesn't seem uncomfortable. He's passing small amounts."
- ●If asked about fits or collapse: "No, he's always woken up."
- ●If asked about pupils: "They look very small, the black bit in the middle, but the light in the room is dim."
- ●If asked about patches, alcohol or sleeping tablets: "No."
Responses to Management (The Negotiation Phase)
- ●If the doctor says the morphine should be paused or lowered:
- ●Reaction: Alarmed. "But what about his pain? He was in agony last week." She accepts if told that the dose is more than his body can clear at the moment, that the pain relief will be adjusted rather than stopped, and that someone will help if the pain returns. She asks, "Do I give the liquid morphine if he asks for it tonight?" and "Should I stop everything?"
- ●If the doctor suggests a visit, blood tests or admission:
- ●Reaction: She is relieved by a visit today. "Yes please, can someone come this afternoon?" If hospital or hospice admission is suggested, she hesitates: "He made me promise." She accepts a short stay if it is explained as a way to get him back home, with the palliative team involved, and asks, "Will he be able to come home?"
- ●If the doctor explains what is causing it:
- ●Reaction: She asks, "Is it his brain, or is it the tablets?" and "Is it my fault?" If told it looks like a side effect of the morphine, that his kidneys may be struggling because he is so dry, and that this can often be put right, she cries a little: "I thought I'd poisoned him." She asks whether the confusion will clear.
- ●If the doctor explains the cause or the plan (or, if not yet raised by the end of the plan, as a last question):
- ●Reaction: She asks quietly, "Is this the beginning of the end? Please be honest with me." If the answer is evasive, she says, "That's not an answer." If told that this particular problem is often reversible but his cancer is serious and the doctor cannot say how long, she says, "Thank you for not just telling me it's fine. I needed to hear that."
- ●If the doctor gives safety netting or what to do tonight:
- ●Reaction: Wants specifics. If vague, such as "ring if it gets worse": "Worse how? What exactly would I look for?" She repeats back clear instructions about when to ring 999, who to ring out of hours and what to do with the next tablets. She asks, "What if he won't wake? Would I be wasting their time?" She will ask Fiona to stay tonight.
- ●If the doctor offers support for her:
- ●Reaction: Surprised and tearful. "Nobody's asked how I am." She accepts the offer of the nurse's number and says she will ring Janet and Fiona.
Mark Scheme
Domain 1: Data Gathering and Diagnosis
Domain 2: Clinical Management and Medical Complexity
Domain 3: Relating to Others
Clinical Learning Points
The Core Dilemma and the Model Plan
- ●Alasdair has stage 4 lung cancer with bone metastases. His morphine was raised six days ago, his pain is now controlled, and he has become drowsy and muddled with visual hallucinations and myoclonic jerks (sudden, brief muscle jumps). The station tests whether the candidate recognises opioid toxicity, looks for the reason a previously tolerated drug has accumulated, and acts today without leaving him in pain.
- ●The model plan has six parts. Check breathing and rousability by phone to decide urgency. Arrange a face to face review the same day. Hold or reduce the morphine and the extra doses until he is seen. Check urea, electrolytes and eGFR (estimated glomerular filtration rate) with calcium, a full blood count and inflammatory markers. Speak to the specialist palliative team today. Give specific safety netting, with a review within 24 hours.
- ●Acceptable alternatives: a home visit by the GP, a hospice assessment, or a same day hospital or acute oncology assessment, as long as it happens today with the palliative team involved. If pain is controlled, reducing the dose is the first step; if it is not, or kidney function is poor, a switch to a different opioid on specialist advice is reasonable. A same day admission is acceptable if home care cannot be made safe.
Recognising Opioid Toxicity
- ●Opioid toxicity is a spectrum, from drowsiness and vivid dreams through visual hallucinations, delirium and myoclonus to respiratory depression. The BNF lists drowsiness, confusion, hallucination, myoclonus and miosis among opioid adverse effects. Hallucinations seen at the edge of vision, with some insight, and twitching on drifting off to sleep are typical early signs, and small pupils support it.
- ●The timing matters. Drowsiness is common after starting or raising an opioid and usually settles within a few days. NICE CG140 and CKS advise that persistent or moderate to severe central nervous system effects should lead to a dose reduction if pain is controlled, or a switch of opioid if pain is not.
- ●Pain control is itself a clue. When pain has improved and the person becomes sedated, the dose is more than they need.
- ●The urgent question for a telephone call is whether breathing is slow, shallow or pausing, or whether he cannot be woken. These need 999. A breathing rate of about 15 with no pauses and rousability to voice allows a same day review.
Why It Happened: Dehydration and Renal Function
- ●The BNF says that in renal impairment morphine's opioid effects are increased and prolonged, with increased cerebral sensitivity, so use should be avoided or the dose reduced (the active morphine metabolites are renally cleared, which is the usual explanation). CKS advises that a lower or less frequent dose may be preferable, or a different opioid more appropriate, with specialist palliative advice. NICE CG140 also says to seek specialist advice in moderate to severe renal impairment.
- ●Alasdair's last eGFR was 61, but he has since had chemotherapy, two days of vomiting, about three days of hardly drinking, dark scanty urine, and he kept taking ramipril. Acute kidney injury is likely, so today's urea and electrolytes decide the dose.
- ●NICE NG148 says to consider temporarily stopping ACE inhibitors and ARBs in adults with diarrhoea, vomiting or sepsis until their clinical condition has improved and stabilised. This is the usual sick day approach: pause ramipril while he is dry, then restart once eating and drinking and kidney function is checked. Continuing it is not a fail, but reviewing it is expected.
Other Causes to Exclude
- ●CKS advises excluding illness or other drugs that mimic opioid adverse effects, for example dehydration. In advanced cancer, consider hypercalcaemia (thirst, constipation, drowsiness, confusion), infection, urinary retention, constipation, brain metastases, other sedating medicines and uraemia.
- ●Alasdair has bone metastases, so a serum calcium is essential. Headache, focal weakness or speech change would raise the concern for brain metastases; his absence of these makes toxicity far more likely.
- ●Treat reversible factors at the same time: fluids as judged at the review, laxatives after five days without a bowel motion, review of ramipril, and an antiemetic if nausea returns.
Adjusting the Opioid
- ●First step: do not give the next modified release dose, or give a reduced dose, and stop the extra doses of liquid morphine until he is reviewed. A common approach is to stop or hold until alert, then restart at a lower dose once renal function is known, with a clear breakthrough plan.
- ●Do not stop all pain relief suddenly. Withdrawing opioids with no breakthrough plan risks a pain crisis, and Alasdair's bone pain was severe a week ago. Paracetamol should continue.
- ●If pain is uncontrolled at a lower dose, or if kidney function is poor, specialist palliative care may switch to another strong opioid. The BNF names oxycodone, buprenorphine, fentanyl and hydromorphone as options on specialist advice when morphine is not tolerated, and none is expected from the candidate. CKS says to seek specialist advice or follow local guidance on the choice of opioid and dose, because conversion ratios differ. Do not improvise this on the phone.
- ●When incident (movement related) pain is counted, CKS advises excluding it from the dose calculation, as including it can cause sedation or toxicity.
- ●Naloxone is for life threatening respiratory depression, not for drowsiness and hallucinations. The BNF cautions that in palliative care it risks returning pain and acute withdrawal, and that overdose doses are not appropriate when a continued therapeutic effect is needed. If it is ever used, it is in small titrated doses on specialist advice.
Pain Beyond the Opioid
- ●CKS advises seeking specialist advice when pain is hard to manage, because secondary care can offer radiotherapy, bisphosphonates or nerve blocks for bone pain. Reducing opioid need by treating the pain differently is a good long term strategy.
- ●Continue regular paracetamol and review whether other adjuvants are needed after the acute episode.
Place of Care, Advance Care Planning and the Carer
- ●Alasdair has a form recording that he would like to be at home, not resuscitated, and that hospital is acceptable if something can be fixed quickly. Opioid toxicity is a reversible problem, so a short admission or hospice stay may fit his wishes, but home treatment with a same day visit is equally good if it is safe. The decision is shared with Moira and, where possible, with Alasdair.
- ●Moira has had about four hours of sleep a night and has promised him "no more hospitals". Acknowledge the promise, explain what a short stay would achieve, and check support, including Fiona staying and the out of hours palliative advice line.
- ●Make sure the out of hours service and the community palliative nurse know the plan. A phone review within 24 hours is expected.
Safety Netting
- ●Give clear triggers for 999: he cannot be woken, his breathing is very slow or has long pauses, he has a fit or continuous jerking, or he turns blue. Give the out of hours number for anything else, such as new vomiting, uncontrolled pain, or hardly any urine.
- ●Tell Moira what to do with the next tablets, who is coming and when, and that she will not be wasting anyone's time by ringing.
Communication Points
- ●Moira's guilt is real. State that she gave exactly what was prescribed, and that the dose rise worked for his pain but is now more than his body can clear.
- ●Explain in plain words: the morphine has built up because he is dry and his kidneys are slow, and this causes sleepiness, seeing things and twitching. This is not madness, and it is not necessarily the cancer spreading.
- ●Answer "is he dying?" honestly: the toxicity is often reversible, his cancer is serious, and the doctor cannot predict how long he has.
Common Mistakes in This Station
- ●Attributing the symptoms to brain metastases or terminal decline and not reducing the opioid.
- ●Raising the morphine because he is sleepy and may be in pain, or telling Moira to give the liquid morphine as usual.
- ●Stopping all morphine with no breakthrough or pain plan.
- ●Managing by phone alone, with no same day review and no bloods.
- ●Not checking breathing rate and rousability, or missing the need for 999 if they are abnormal.
- ●Ignoring dehydration, ramipril, constipation and calcium.
- ●Prescribing an antipsychotic or sedative for the hallucinations before reducing the opioid.
- ●Not involving specialist palliative care today.
- ●Safety netting with "ring if he gets worse" and no named symptoms.
- ●Overriding his wish to stay at home without exploring options, or forgetting Moira's exhaustion.
Mapped to the RCGP curriculum topic: People at the End of Life.
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